Seroatlas · Human Serome Atlas

MUC13

Mucin-13

Also known as: DRCC1, MUC13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3R2
Gene: MUC13
Ensembl: ENSG00000173702
Chromosome: 3
Canonical length: 512 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted to digestive system
Quaternary structure: Homodimer

OverviewNCBI Gene

Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al., 2001 [PubMed 11278439]).[supplied by OMIM, Jul 2008]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>Q9H3R2|MUC13
     1  MKAIIHLTLL ALLSVNTATN QGNSADAVTT TETATSGPTV AAADTTETNF PETASTTANT
    61  PSFPTATSPA PPIISTHSSS TIPTPAPPII STHSSSTIPI PTAADSESTT NVNSLATSDI
   121  ITASSPNDGL ITMVPSETQS NNEMSPTTED NQSSGPPTGT ALLETSTLNS TGPSNPCQDD
   181  PCADNSLCVK LHNTSFCLCL EGYYYNSSTC KKGKVFPGKI SVTVSETFDP EEKHSMAYQD
   241  LHSEITSLFK DVFGTSVYGQ TVILTVSTSL SPRSEMRADD KFVNVTIVTI LAETTSDNEK
   301  TVTEKINKAI RSSSSNFLNY DLTLRCDYYG CNQTADDCLN GLACDCKSDL QRPNPQSPFC
   361  VASSLKCPDA CNAQHKQCLI KKSGGAPECA CVPGYQEDAN GNCQKCAFGY SGLDCKDKFQ
   421  LILTIVGTIA GIVILSMIIA LIVTARSNNK TKHIEEENLI DEDFQNLKLR STGFTNLGAE
   481  GSVFPKVRIT ASRDSQMQNP YSRHSSMPRP DY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 579 nTPM

Expression across tissuesHPA

Tissue

duodenum: 579 nTPM
small intestine: 474 nTPM
colon: 286 nTPM
rectum: 283 nTPM
appendix: 59 nTPM
gallbladder: 45 nTPM

Single-cell type

enterocytes: 1,143 nCPM
colonocytes: 1,013 nCPM
goblet cells: 931 nCPM
enteric transient amplifying cells: 272 nCPM
endometrial ciliated cells: 205 nCPM
neuroendocrine cells: 200 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.7 nTPM
medulla oblongata: 0.5 nTPM
cerebral cortex: 0.1 nTPM
hypothalamus: 0.1 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 0.87

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

maintenance of gastrointestinal epithelium

Molecular functions

protein homodimerization activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MUC13 as an antibody target. Whether an autoantibody or antibody against MUC13 could matter depends on whether native MUC13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MUC13 is annotated at the cell surface, where native MUC13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MUC13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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