Seroatlas · Human Serome Atlas

MUC12

Mucin-12

Also known as: MUC11, MUC12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKN1
Gene
MUC12
Ensembl
ENSG00000205277
Chromosome
7
Canonical length
5478 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

5478 residues, UniProt reviewed canonical sequence.

>Q9UKN1|MUC12
     1  MLVIWILTLA LRLCASVTTV TPEGSAVHKA ISQQGTLWTG EVLEKQTVEQ GKSTLRRQKN
    61  HFHRSAGELR CRNALKDEGA SAGWSVMFAG ESVVVLVHLW MTGARVKNLG LVEFASPGDD
   121  GDGRAEGFSL GLPLSEQARA AGAREKERQE TVINHSTFSG FSQITGSTVN TSIGGNTTSA
   181  STPSSSDPFT TFSDYGVSVT FITGSTATKH FLDSSTNSGH SEESTVSHSG PGATGTTLFP
   241  SHSATSVFVG EPKTSPITSA SMETTALPGS TTTAGLSEKS TTFYSSPRSP DRTLSPARTT
   301  SSGVSEKSTT SHSRPGPTHT IAFPDSTTMP GVSQESTASH SIPGSTDTTL SPGTTTPSSL
   361  GPESTTFHSS PGYTKTTRLP DNTTTSGLLE ASTPVHSSTG SPHTTLSPSS STTHEGEPTT
   421  FQSWPSSKDT SPAPSGTTSA FVKLSTTYHS SPSSTPTTHF SASSTTLGHS EESTPVHSSP
   481  VATATTPPPA RSATSGHVEE STAYHRSPGS TQTMHFPESS TTSGHSEESA TFHGSTTHTK
   541  SSTPSTTAAL AHTSYHSSLG STETTHFRDS STISGRSEES KASHSSPDAM ATTVLPAGST
   601  PSVLVGDSTP SPISSGSMET TALPGSTTKP GLSEKSTTFY SSPRSPDTTH LPASMTSSGV
   661  SEESTTSHSR PGSTHTTAFP GSTTMPGLSQ ESTASHSSPG PTDTTLSPGS TTASSLGPEY
   721  TTFHSRPGST ETTLLPDNTT ASGLLEASMP VHSSTRSPHT TLSPAGSTTR QGESTTFHSW
   781  PSSKDTRPAP PTTTSAFVEP STTSHGSPSS IPTTHISARS TTSGLVEEST TYHSSPGSTQ
   841  TMHFPESDTT SGRGEESTTS HSSTTHTISS APSTTSALVE EPTSYHSSPG STATTHFPDS
   901  STTSGRSEES TASHSSQDAT GTIVLPARST TSVLLGESTT SPISSGSMET TALPGSTTTP
   961  GLSERSTTFH SSPRSPATTL SPASTTSSGV SEESTTSRSR PGSTHTTAFP DSTTTPGLSR
  1021  HSTTSHSSPG STDTTLLPAS TTTSGPSQES TTSHSSSGST DTALSPGSTT ALSFGQESTT
  1081  FHSNPGSTHT TLFPDSTTSS GIVEASTRVH SSTGSPRTTL SPASSTSPGL QGESTAFQTH
  1141  PASTHTTPSP PSTATAPVEE STTYHRSPGS TPTTHFPASS TTSGHSEKST IFHSSPDASG
  1201  TTPSSAHSTT SGRGESTTSR ISPGSTEITT LPGSTTTPGL SEASTTFYSS PRSPTTTLSP
  1261  ASMTSLGVGE ESTTSRSQPG STHSTVSPAS TTTPGLSEES TTVYSSSRGS TETTVFPHST
  1321  TTSVHGEEPT TFHSRPASTH TTLFTEDSTT SGLTEESTAF PGSPASTQTG LPATLTTADL
  1381  GEESTTFPSS SGSTGTKLSP ARSTTSGLVG ESTPSRLSPS STETTTLPGS PTTPSLSEKS
  1441  TTFYTSPRSP DATLSPATTT SSGVSEESST SHSQPGSTHT TAFPDSTTTS DLSQEPTTSH
  1501  SSQGSTEATL SPGSTTASSL GQQSTTFHSS PGDTETTLLP DDTITSGLVE ASTPTHSSTG
  1561  SLHTTLTPAS STSAGLQEES TTFQSWPSSS DTTPSPPGTT AAPVEVSTTY HSRPSSTPTT
  1621  HFSASSTTLG RSEESTTVHS SPGATGTALF PTRSATSVLV GEPTTSPISS GSTETTALPG
  1681  STTTAGLSEK STTFYSSPRS PDTTLSPAST TSSGVSEEST TSHSRPGSTH TTAFPGSTTM
  1741  PGVSQESTAS HSSPGSTDTT LSPGSTTASS LGPESTTFHS SPGSTETTLL PDNTTASGLL
  1801  EASTPVHSST GSPHTTLSPA GSTTRQGEST TFQSWPSSKD TMPAPPTTTS AFVELSTTSH
  1861  GSPSSTPTTH FSASSTTLGR SEESTTVHSS PVATATTPSP ARSTTSGLVE ESTAYHSSPG
  1921  STQTMHFPES STASGRSEES RTSHSSTTHT ISSPPSTTSA LVEEPTSYHS SPGSTATTHF
  1981  PDSSTTSGRS EESTASHSSQ DATGTIVLPA RSTTSVLLGE STTSPISSGS METTALPGST
  2041  TTPGLSEKST TFHSSPRSPA TTLSPASTTS SGVSEESTTS HSRPGSTHTT AFPDSTTTPG
  2101  LSRHSTTSHS SPGSTDTTLL PASTTTSGPS QESTTSHSSP GSTDTALSPG STTALSFGQE
  2161  STTFHSSPGS THTTLFPDST TSSGIVEAST RVHSSTGSPR TTLSPASSTS PGLQGESTAF
  2221  QTHPASTHTT PSPPSTATAP VEESTTYHRS PGSTPTTHFP ASSTTSGHSE KSTIFHSSPD
  2281  ASGTTPSSAH STTSGRGEST TSRISPGSTE ITTLPGSTTT PGLSEASTTF YSSPRSPTTT
  2341  LSPASMTSLG VGEESTTSRS QPGSTHSTVS PASTTTPGLS EESTTVYSSS PGSTETTVFP
  2401  RTPTTSVRGE EPTTFHSRPA STHTTLFTED STTSGLTEES TAFPGSPAST QTGLPATLTT
  2461  ADLGEESTTF PSSSGSTGTT LSPARSTTSG LVGESTPSRL SPSSTETTTL PGSPTTPSLS
  2521  EKSTTFYTSP RSPDATLSPA TTTSSGVSEE SSTSHSQPGS THTTAFPDST TTPGLSRHST
  2581  TSHSSPGSTD TTLLPASTTT SGPSQESTTS HSSPGSTDTA LSPGSTTALS FGQESTTFHS
  2641  SPGSTHTTLF PDSTTSSGIV EASTRVHSST GSPRTTLSPA SSTSPGLQGE STTFQTHPAS
  2701  THTTPSPPST ATAPVEESTT YHRSPGSTPT THFPASSTTS GHSEKSTIFH SSPDASGTTP
  2761  SSAHSTTSGR GESTTSRISP GSTEITTLPG STTTPGLSEA STTFYSSPRS PTTTLSPASM
  2821  TSLGVGEEST TSRSQPGSTH STVSPASTTT PGLSEESTTV YSSSPGSTET TVFPRSTTTS
  2881  VRGEEPTTFH SRPASTHTTL FTEDSTTSGL TEESTAFPGS PASTQTGLPA TLTTADLGEE
  2941  STTFPSSSGS TGTTLSPARS TTSGLVGEST PSRLSPSSTE TTTLPGSPTT PSLSEKSTTF
  3001  YTSPRSPDAT LSPATTTSSG VSEESSTSHS QPGSTHTTAF PDSTTTSGLS QEPTASHSSQ
  3061  GSTEATLSPG STTASSLGQQ STTFHSSPGD TETTLLPDDT ITSGLVEAST PTHSSTGSLH
  3121  TTLTPASSTS AGLQEESTTF QSWPSSSDTT PSPPGTTAAP VEVSTTYHSR PSSTPTTHFS
  3181  ASSTTLGRSE ESTTVHSSPG ATGTALFPTR SATSVLVGEP TTSPISSGST ETTALPGSTT
  3241  TAGLSEKSTT FYSSPRSPDT TLSPASTTSS GVSEESTTSH SRPGSTHTTA FPGSTTMPGV
  3301  SQESTASHSS PGSTDTTLSP GSTTASSLGP ESTTFHSGPG STETTLLPDN TTASGLLEAS
  3361  TPVHSSTGSP HTTLSPAGST TRQGESTTFQ SWPNSKDTTP APPTTTSAFV ELSTTSHGSP
  3421  SSTPTTHFSA SSTTLGRSEE STTVHSSPVA TATTPSPARS TTSGLVEEST TYHSSPGSTQ
  3481  TMHFPESDTT SGRGEESTTS HSSTTHTISS APSTTSALVE EPTSYHSSPG STATTHFPDS
  3541  STTSGRSEES TASHSSQDAT GTIVLPARST TSVLLGESTT SPISSGSMET TALPGSTTTP
  3601  GLSEKSTTFH SSPRSPATTL SPASTTSSGV SEESTTSHSR PGSTHTTAFP DSTTTPGLSR
  3661  HSTTSHSSPG STDTTLLPAS TTTSGSSQES TTSHSSSGST DTALSPGSTT ALSFGQESTT
  3721  FHSSPGSTHT TLFPDSTTSS GIVEASTRVH SSTGSPRTTL SPASSTSPGL QGESTAFQTH
  3781  PASTHTTPSP PSTATAPVEE STTYHRSPGS TPTTHFPASS TTSGHSEKST IFHSSPDASG
  3841  TTPSSAHSTT SGRGESTTSR ISPGSTEITT LPGSTTTPGL SEASTTFYSS PRSPTTTLSP
  3901  ASMTSLGVGE ESTTSRSQPG STHSTVSPAS TTTPGLSEES TTVYSSSPGS TETTVFPRST
  3961  TTSVRREEPT TFHSRPASTH TTLFTEDSTT SGLTEESTAF PGSPASTQTG LPATLTTADL
  4021  GEESTTFPSS SGSTGTKLSP ARSTTSGLVG ESTPSRLSPS STETTTLPGS PTTPSLSEKS
  4081  TTFYTSPRSP DATLSPATTT SSGVSEESST SHSQPGSTHT TAFPDSTTTS GLSQEPTTSH
  4141  SSQGSTEATL SPGSTTASSL GQQSTTFHSS PGDTETTLLP DDTITSGLVE ASTPTHSSTG
  4201  SLHTTLTPAS STSTGLQEES TTFQSWPSSS DTTPSPPSTT AVPVEVSTTY HSRPSSTPTT
  4261  HFSASSTTLG RSEESTTVHS SPGATGTALF PTRSATSVLV GEPTTSPISS GSTETTALPG
  4321  STTTAGLSEK STTFYSSPRS PDTTLSPAST TSSGVSEEST TSHSRPGSMH TTAFPSSTTM
  4381  PGVSQESTAS HSSPGSTDTT LSPGSTTASS LGPESTTFHS SPGSTETTLL PDNTTASGLL
  4441  EASTPVHSST GSPHTTLSPA GSTTRQGEST TFQSWPNSKD TTPAPPTTTS AFVELSTTSH
  4501  GSPSSTPTTH FSASSTTLGR SEESTTVHSS PVATATTPSP ARSTTSGLVE ESTTYHSSPG
  4561  STQTMHFPES NTTSGRGEES TTSHSSTTHT ISSAPSTTSA LVEEPTSYHS SPGSTATTHF
  4621  PDSSTTSGRS EESTASHSSQ DATGTIVLPA RSTTSVLLGE STTSPISSGS METTALPGST
  4681  TTPGLSEKST TFHSSPSSTP TTHFSASSTT LGRSEESTTV HSSPVATATT PSPARSTTSG
  4741  LVEESTAYHS SPGSTQTMHF PESSTASGRS EESRTSHSST THTISSPPST TSALVEEPTS
  4801  YHSSPGSIAT THFPESSTTS GRSEESTASH SSPDTNGITP LPAHFTTSGR IAESTTFYIS
  4861  PGSMETTLAS TATTPGLSAK STILYSSSRS PDQTLSPASM TSSSISGEPT SLYSQAESTH
  4921  TTAFPASTTT SGLSQESTTF HSKPGSTETT LSPGSITTSS FAQEFTTPHS QPGSALSTVS
  4981  PASTTVPGLS EESTTFYSSP GSTETTAFSH SNTMSIHSQQ STPFPDSPGF THTVLPATLT
  5041  TTDIGQESTA FHSSSDATGT TPLPARSTAS DLVGEPTTFY ISPSPTYTTL FPASSSTSGL
  5101  TEESTTFHTS PSFTSTIVST ESLETLAPGL CQEGQIWNGK QCVCPQGYVG YQCLSPLESF
  5161  PVETPEKLNA TLGMTVKVTY RNFTEKMNDA SSQEYQNFST LFKNRMDVVL KGDNLPQYRG
  5221  VNIRRLLNGS IVVKNDVILE ADYTLEYEEL FENLAEIVKA KIMNETRTTL LDPDSCRKAI
  5281  LCYSEEDTFV DSSVTPGFDF QEQCTQKAAE GYTQFYYVDV LDGKLACVNK CTKGTKSQMN
  5341  CNLGTCQLQR SGPRCLCPNT NTHWYWGETC EFNIAKSLVY GIVGAVMAVL LLALIILIIL
  5401  FSLSQRKRHR EQYDVPQEWR KEGTPGIFQK TAIWEDQNLR ESRFGLENAY NNFRPTLETV
  5461  DSGTELHIQR PEMVASTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 64 nTPM
  • colon: 47 nTPM
  • prostate: 6 nTPM
  • small intestine: 2.4 nTPM
  • appendix: 1.8 nTPM
  • smooth muscle: 0.8 nTPM

Single-cell type

  • colonocytes: 1,215 nCPM
  • enteric stem cells: 394 nCPM
  • enteric transient amplifying cells: 276 nCPM
  • goblet cells: 220 nCPM
  • paneth cells: 139 nCPM
  • enterocytes: 112 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.8 nTPM
  • hypothalamus: 0.8 nTPM
  • white matter: 0.8 nTPM
  • basal ganglia: 0.6 nTPM
  • hippocampal formation: 0.6 nTPM
  • amygdala: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0
gnomAD missense Z
-6.32
DepMap mean gene effect
0.22
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MUC12 as an antibody target. Whether an autoantibody or antibody against MUC12 could matter depends on whether native MUC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MUC12 is annotated at the cell surface, where native MUC12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MUC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MUC12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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