Seroatlas · Human Serome Atlas

MTX3

Metaxin-3

Also known as: MTX3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5HYI7
Gene
MTX3
Ensembl
ENSG00000177034
Chromosome
5
Canonical length
312 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Predicted to be involved in mitochondrion organization. Located in mitochondrion. Part of MIB complex and SAM complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q5HYI7|MTX3
     1  MAAPLELSCW GGGWGLPSVH SESLVVMAYA KFSGAPLKVN VIDNTWRGSR GDVPILTTED
    61  DMVSQPAKIL NFLRKQKYNA DYELSAKQGA DTLAYIALLE EKLLPAVLHT FWVESDNYFT
   121  VTKPWFASQI PFPLSLILPG RMSKGALNRI LLTRGQPPLY HLREVEAQIY RDAKECLNLL
   181  SNRLGTSQFF FGDTPSTLDA YVFGFLAPLY KVRFPKVQLQ EHLKQLSNLC RFCDDILSSY
   241  FRLSLGGISP AGQETVDANL QKLTQLVNKE SNLIEKMDDN LRQSPQLPPR KLPTLKLTPA
   301  EEENNSFQRL SP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 11 nTPM
  • retina: 11 nTPM
  • ovary: 9.4 nTPM
  • basal ganglia: 8.2 nTPM
  • cerebellum: 7.9 nTPM
  • lymph node: 7.7 nTPM

Single-cell type

  • cone photoreceptor cells: 50 nCPM
  • gonadotrophs: 42 nCPM
  • retinal pigment epithelial cells: 38 nCPM
  • adrenal medulla cells: 32 nCPM
  • bergmann glia: 32 nCPM
  • brain inhibitory neurons: 30 nCPM

Immune cell

  • memory B-cell: 0.8 nTPM
  • naive CD4 T-cell: 0.8 nTPM
  • gdT-cell: 0.6 nTPM
  • memory CD4 T-cell: 0.6 nTPM
  • naive CD8 T-cell: 0.6 nTPM
  • memory CD8 T-cell: 0.5 nTPM

Brain region

  • cerebral cortex: 18 nTPM
  • basal ganglia: 18 nTPM
  • hypothalamus: 18 nTPM
  • pons: 18 nTPM
  • hippocampal formation: 18 nTPM
  • midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTX3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTX3 as an antibody target. Whether an autoantibody or antibody against MTX3 could matter depends on whether native MTX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTX3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MTX3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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