Seroatlas · Human Serome Atlas

MTURN

Maturin

Also known as: C7orf41, Ells1, FLJ25903, MTURN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3F0
Gene: MTURN
Ensembl: ENSG00000180354
Chromosome: 7
Canonical length: 131 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Involved in negative regulation of NF-kappaB transcription factor activity; positive regulation of MAPK cascade; and positive regulation of megakaryocyte differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>Q8N3F0|MTURN
     1  MDFQQLADVA EKWCSNTPFE LIATEETERR MDFYADPGVS FYVLCPDNGC GDNFHVWSES
    61  EDCLPFLQLA QDYISSCGKK TLHEVLEKVF KSFRPLLGLP DADDDAFEEY SADVEEEEPE
   121  ADHPQMGVSQ Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTURN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 1,847 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 1,847 nTPM
midbrain: 1,515 nTPM
hippocampal formation: 993 nTPM
amygdala: 914 nTPM
basal ganglia: 767 nTPM
hypothalamus: 723 nTPM

Single-cell type

platelets: 1,053 nCPM
megakaryocytes: 260 nCPM
distal convoluted tubule cells: 125 nCPM
loop of henle epithelial cells: 121 nCPM
hematopoietic stem cells: 112 nCPM
epididymal principal cells: 111 nCPM

Immune cell

basophil: 8.3 nTPM
eosinophil: 3.6 nTPM
neutrophil: 2.2 nTPM
NK-cell: 2.1 nTPM
total PBMC: 1.4 nTPM
plasmacytoid DC: 1 nTPM

Brain region

white matter: 1,709 nTPM
basal ganglia: 1,516 nTPM
spinal cord: 1,433 nTPM
medulla oblongata: 1,414 nTPM
pons: 1,380 nTPM
thalamus: 1,338 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.44
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Maturin
Domain of unknown function (DUF4581)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTURN as an antibody target. Whether an autoantibody or antibody against MTURN could matter depends on whether native MTURN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTURN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTURN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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