Seroatlas · Human Serome Atlas

MTRF1L

Peptide chain release factor 1-like, mitochondrial

Also known as: HMRF1L, mtRF1a, RF1ML_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UGC7
Gene: MTRF1L
Ensembl: ENSG00000112031
Chromosome: 6
Canonical length: 380 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene plays a role in mitochondrial translation termination, and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons, but has no in vitro activity against UGA, which encodes tryptophan in human mitochondrion, or, the mitochondrial non-cognate stop codons, AGA and AGG. This protein shares sequence similarity to bacterial release factors. Pseudogenes of this gene are found on chromosomes 4, 8, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>Q9UGC7|MTRF1L
     1  MRSRVLWGAA RWLWPRRAVG PARRPLSSGS PPLEELFTRG GPLRTFLERQ AGSEAHLKVR
    61  RPELLAVIKL LNEKERELRE TEHLLHDENE DLRKLAENEI TLCQKEITQL KHQIILLLVP
   121  SEETDENDLI LEVTAGVGGQ EAMLFTSEIF DMYQQYAAFK RWHFETLEYF PSELGGLRHA
   181  SASIGGSEAY RHMKFEGGVH RVQRVPKTEK QGRVHTSTMT VAILPQPTEI NLVINPKDLR
   241  IDTKRASGAG GQHVNTTDSA VRIVHLPTGV VSECQQERSQ LKNKELAMTK LRAKLYSMHL
   301  EEEINKRQNA RKIQIGSKGR SEKIRTYNFP QNRVTDHRIN KTLHDLETFM QGDYLLDELV
   361  QSLKEYADYE SLVEIISQKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTRF1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

tongue: 21 nTPM
skeletal muscle: 17 nTPM
choroid plexus: 14 nTPM
heart muscle: 11 nTPM
retina: 9.6 nTPM
kidney: 9.4 nTPM

Single-cell type

late spermatids: 75 nCPM
late primary spermatocytes: 74 nCPM
granulosa cells: 61 nCPM
cardiomyocytes: 50 nCPM
megakaryocytes: 50 nCPM
early spermatids: 46 nCPM

Immune cell

basophil: 10 nTPM
eosinophil: 7.1 nTPM
non-classical monocyte: 7 nTPM
intermediate monocyte: 5.2 nTPM
T-reg: 4 nTPM
total PBMC: 4 nTPM

Brain region

choroid plexus: 25 nTPM
cerebellum: 23 nTPM
pons: 20 nTPM
white matter: 19 nTPM
basal ganglia: 18 nTPM
medulla oblongata: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: -0.54
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translational termination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTRF1L as an antibody target. Whether an autoantibody or antibody against MTRF1L could matter depends on whether native MTRF1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTRF1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTRF1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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