Seroatlas · Human Serome Atlas

MTRF1

Peptide chain release factor 1, mitochondrial

Also known as: MGC47721, MTTRF1, RF1, RF1M_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75570
Gene: MTRF1
Ensembl: ENSG00000120662
Chromosome: 13
Canonical length: 445 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>O75570|MTRF1
     1  MNRHLCVWLF RHPSLNGYLQ CHIQLHSHQF RQIHLDTRLQ VFRQNRNCIL HLLSKNWSRR
    61  YCHQDTKMLW KHKALQKYME NLSKEYQTLE QCLQHIPVNE ENRRSLNRRH AELAPLAAIY
   121  QEIQETEQAI EELESMCKSL NKQDEKQLQE LALEERQTID QKINMLYNEL FQSLVPKEKY
   181  DKNDVILEVT AGRTTGGDIC QQFTREIFDM YQNYSCYKHW QFELLNYTPA DYGGLHHAAA
   241  RISGDGVYKH LKYEGGIHRV QRIPEVGLSS RMQRIHTGTM SVIVLPQPDE VDVKLDPKDL
   301  RIDTFRAKGA GGQHVNKTDS AVRLVHIPTG LVVECQQERS QIKNKEIAFR VLRARLYQQI
   361  IEKDKRQQQS ARKLQVGTRA QSERIRTYNF TQDRVSDHRI AYEVRDIKEF LCGGKGLDQL
   421  IQRLLQSADE EAIAELLDEH LKSAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTRF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 15 nTPM
testis: 13 nTPM
skeletal muscle: 13 nTPM
tongue: 12 nTPM
lymph node: 12 nTPM
pancreas: 12 nTPM

Single-cell type

late primary spermatocytes: 67 nCPM
choroid plexus epithelial cells: 61 nCPM
sertoli cells: 50 nCPM
myonuclei: 42 nCPM
cardiomyocytes: 32 nCPM
adrenal cortex cells: 31 nCPM

Immune cell

naive CD8 T-cell: 7.9 nTPM
myeloid DC: 5.4 nTPM
naive CD4 T-cell: 5.4 nTPM
MAIT T-cell: 5.3 nTPM
memory B-cell: 5 nTPM
eosinophil: 4.9 nTPM

Brain region

choroid plexus: 15 nTPM
pons: 8.1 nTPM
cerebellum: 7.7 nTPM
cerebral cortex: 7.3 nTPM
medulla oblongata: 7.2 nTPM
thalamus: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translational termination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTRF1 as an antibody target. Whether an autoantibody or antibody against MTRF1 could matter depends on whether native MTRF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTRF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTRF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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