Seroatlas · Human Serome Atlas

MTNAP1

Mitochondrial nucleoid-associated protein 1

Also known as: C17orf80, CQ080_HUMAN, FLJ20721, HLC-8, MIG3, SPEP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSJ5
Gene
MTNAP1
Ensembl
ENSG00000141219
Chromosome
17
Canonical length
609 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to be involved in cell population proliferation; mitochondrial DNA metabolic process; and positive regulation of mitochondrial DNA replication. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

609 residues, UniProt reviewed canonical sequence.

>Q9BSJ5|MTNAP1
     1  MSDNPPRMEV CPYCKKPFKR LKSHLPYCKM IGPTIPTDQK VYQSKPATLP RAKKMKGPIK
    61  DLIKAKGKEL ETENEERNSK LVVDKPEQTV KTFPLPAVGL ERAATTKADK DIKNPIQPSF
   121  KMLKNTKPMT TFQEETKAQF YASEKTSPKR ELAKDLPKSG ESRCNPSEAG ASLLVGSIEP
   181  SLSNQDRKYS STLPNDVQTT SGDLKLDKID PQRQELLVKL LDVPTGDCHI SPKNVSDGVK
   241  RVRTLLSNER DSKGRDHLSG VPTDVTVTET PEKNTESLIL SLKMSSLGKI QVMEKQEKGL
   301  TLGVETCGSK GNAEKSMSAT EKQERTVMSH GCENFNTRDS VTGKESQGER PHLSLFIPRE
   361  TTYQFHSVSQ SSSQSLASLA TTFLQEKKAE AQNHHCVPDV KALMESPEGQ LSLEPKSDSQ
   421  FQASHTGCQS PLCSAQRHTP QSPFTNHAAA AGRKTLRSCM GLEWFPELYP GYLGLGVLPG
   481  KPQCWNAMTQ KPQLISPQGE RLSQVSLLER SSTHIRSLEP PAGLTTSNFS LMRLLGAVQK
   541  GWIRCNTTIR KSGFGGITML FTGYFVLCCS WSFRRLKKLC RPLPWKSTVP PCIGVAKTTG
   601  DCRSKTCLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTNAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • testis: 37 nTPM
  • skeletal muscle: 22 nTPM
  • retina: 21 nTPM
  • tongue: 20 nTPM
  • thymus: 16 nTPM
  • parathyroid gland: 15 nTPM

Single-cell type

  • late primary spermatocytes: 192 nCPM
  • early spermatids: 160 nCPM
  • late spermatids: 149 nCPM
  • myonuclei: 36 nCPM
  • thyrotrophs: 31 nCPM
  • cone photoreceptor cells: 29 nCPM

Immune cell

  • basophil: 16 nTPM
  • T-reg: 7.1 nTPM
  • gdT-cell: 6.5 nTPM
  • naive CD8 T-cell: 6.4 nTPM
  • MAIT T-cell: 6.3 nTPM
  • memory CD8 T-cell: 5.8 nTPM

Brain region

  • cerebellum: 24 nTPM
  • basal ganglia: 19 nTPM
  • hypothalamus: 19 nTPM
  • cerebral cortex: 19 nTPM
  • white matter: 18 nTPM
  • hippocampal formation: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Mitochondrial nucleoid-associated protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTNAP1 as an antibody target. Whether an autoantibody or antibody against MTNAP1 could matter depends on whether native MTNAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTNAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTNAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MTNAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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