Seroatlas · Human Serome Atlas

MTIF3

Translation initiation factor IF-3, mitochondrial

Also known as: IF-3mt, IF3(mt), IF3M_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2K0
Gene: MTIF3
Ensembl: ENSG00000122033
Chromosome: 13
Canonical length: 278 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q9H2K0|MTIF3
     1  MAALFLKRLT LQTVKSENSC IRCFGKHILQ KTAPAQLSPI ASAPRLSFLI HAKAFSTAED
    61  TQNEGKKTKK NKTAFSNVGR KISQRVIHLF DEKGNDLGNM HRANVIRLMD ERDLRLVQRN
   121  TSTEPAEYQL MTGLQILQER QRLREMEKAN PKTGPTLRKE LILSSNIGQH DLDTKTKQIQ
   181  QWIKKKHLVQ ITIKKGKNVD VSENEMEEIF HQILQTMPGI ATFSSRPQAV QGGKALMCVL
   241  RAFSKNEEKA YKETQETQER DTLNKDHGND KESNVLHQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTIF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 125 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 125 nTPM
tongue: 102 nTPM
skeletal muscle: 85 nTPM
salivary gland: 78 nTPM
retina: 69 nTPM
kidney: 69 nTPM

Single-cell type

oocytes: 774 nCPM
early spermatids: 634 nCPM
late primary spermatocytes: 604 nCPM
esophageal apical cells: 382 nCPM
late spermatids: 339 nCPM
parietal cells: 327 nCPM

Immune cell

plasmacytoid DC: 88 nTPM
basophil: 86 nTPM
eosinophil: 76 nTPM
myeloid DC: 55 nTPM
classical monocyte: 53 nTPM
intermediate monocyte: 51 nTPM

Brain region

cerebral cortex: 28 nTPM
hypothalamus: 28 nTPM
white matter: 28 nTPM
pons: 27 nTPM
medulla oblongata: 27 nTPM
cerebellum: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Translation initiation factor 3
Translation initiation factor 3, N-terminal
Translation initiation factor 3 (IF-3), N-terminal domain superfamily
Translation initiation factor 3 (IF-3), C-terminal domain superfamily
Translation initiation factor IF-3, N-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTIF3 as an antibody target. Whether an autoantibody or antibody against MTIF3 could matter depends on whether native MTIF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTIF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTIF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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