Seroatlas · Human Serome Atlas

MTFR2

Mitochondrial fission regulator 2

Also known as: DUFD1, FAM54A, MTFR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P444
Gene: MTFR2
Ensembl: ENSG00000146410
Chromosome: 6
Canonical length: 385 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in aerobic respiration and mitochondrial fission. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q6P444|MTFR2
     1  MSLILNILRE MLEYFGVPVE QVLLIWENKD YGSTRSIVRI IGKMLPLEPC RRPNFELIPL
    61  LNSVDSDNCG SMVPSFADIL YVANDEEASY LRFRNSIWKN EEEKVEIFHP LRLVRDPLSP
   121  AVRQKETVKN DLPVNEAAIR KIAALENELT FLRSQIAAIV EMQELKNSTN SSSFGLSDER
   181  ISLGQLSSSR AAHLSVDPDQ LPGSVLSPPP PPPLPPQFSS LQPPCFPPVQ PGSNNICDSD
   241  NPATEMSKQN PAANKTNYSH HSKSQRNKDI PNMLDVLKDM NKVKLRAIER SPGGRPIHKR
   301  KRQNSHWDPV SLISHALKQK FAFQEDDSFE KENRSWESSP FSSPETSRFG HHISQSEGQR
   361  TKEEMVNTKA VDQGISNTSL LNSRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTFR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 15 nTPM
testis: 6.6 nTPM
lymph node: 6 nTPM
thymus: 5.7 nTPM
tonsil: 4.9 nTPM
rectum: 3.5 nTPM

Single-cell type

oocytes: 175 nCPM
extravillous trophoblasts: 34 nCPM
monocyte progenitors: 29 nCPM
early primary spermatocytes: 26 nCPM
late primary spermatocytes: 20 nCPM
erythrocyte progenitors: 19 nCPM

Immune cell

intermediate monocyte: 0.9 nTPM
myeloid DC: 0.9 nTPM
memory CD8 T-cell: 0.7 nTPM
non-classical monocyte: 0.7 nTPM
plasmacytoid DC: 0.7 nTPM
T-reg: 0.7 nTPM

Brain region

hippocampal formation: 0.7 nTPM
midbrain: 0.7 nTPM
thalamus: 0.7 nTPM
white matter: 0.7 nTPM
cerebellum: 0.6 nTPM
cerebral cortex: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MTFR2.

Disease | ImmuneIEDB

Conditions an epitope on MTFR2 was assayed in.

lung adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTFR2 as an antibody target. Whether an autoantibody or antibody against MTFR2 could matter depends on whether native MTFR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTFR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTFR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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