Seroatlas · Human Serome Atlas

MTFR1L

Mitochondrial fission regulator 1-like

Also known as: FAM54B, MFR1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H019
Gene: MTFR1L
Ensembl: ENSG00000117640
Chromosome: 1
Canonical length: 292 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cell Junctions,Mitochondria

OverviewNCBI Gene

Predicted to be involved in aerobic respiration and mitochondrial fission. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q9H019|MTFR1L
     1  MSGMEATVTI PIWQNKPHGA ARSVVRRIGT NLPLKPCARA SFETLPNISD LCLRDVPPVP
    61  TLADIAWIAA DEEETYARVR SDTRPLRHTW KPSPLIVMQR NASVPNLRGS EERLLALKKP
   121  ALPALSRTTE LQDELSHLRS QIAKIVAADA ASASLTPDFL SPGSSNVSSP LPCFGSSFHS
   181  TTSFVISDIT EETEVEVPEL PSVPLLCSAS PECCKPEHKA ACSSSEEDDC VSLSKASSFA
   241  DMMGILKDFH RMKQSQDLNR SLLKEEDPAV LISEVLRRKF ALKEEDISRK GN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTFR1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 224 nTPM

Expression across tissuesHPA

Tissue

tongue: 224 nTPM
skeletal muscle: 208 nTPM
heart muscle: 161 nTPM
adrenal gland: 133 nTPM
parathyroid gland: 100 nTPM
liver: 90 nTPM

Single-cell type

late spermatids: 969 nCPM
late primary spermatocytes: 334 nCPM
platelets: 290 nCPM
early spermatids: 206 nCPM
megakaryocytes: 80 nCPM
early primary spermatocytes: 78 nCPM

Immune cell

eosinophil: 112 nTPM
basophil: 72 nTPM
non-classical monocyte: 59 nTPM
myeloid DC: 55 nTPM
total PBMC: 51 nTPM
intermediate monocyte: 51 nTPM

Brain region

choroid plexus: 67 nTPM
midbrain: 66 nTPM
thalamus: 65 nTPM
basal ganglia: 62 nTPM
hippocampal formation: 60 nTPM
hypothalamus: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.31
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTFR1L as an antibody target. Whether an autoantibody or antibody against MTFR1L could matter depends on whether native MTFR1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTFR1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTFR1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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