Seroatlas · Human Serome Atlas

MTFR1

Mitochondrial fission regulator 1

Also known as: CHPPR, FAM54A2, KIAA0009, MTFR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15390
Gene: MTFR1
Ensembl: ENSG00000066855
Chromosome: 8
Canonical length: 333 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>Q15390|MTFR1
     1  MLGWIKRLIR MVFQQVGVSM QSVLWSRKPY GSSRSIVRKI GTNLSLIQCP RVQFQINSHA
    61  TEWSPSHPGE DAVASFADVG WVAKEEGECS ARLRTEVRSR PPLQDDLLFF EKAPSRQISL
   121  PDLSQEEPQL KTPALANEEA LQKICALENE LAALRAQIAK IVTQQEQQNL TAGDLDSTTF
   181  GTIPPHPPPP PPPLPPPALG LHQSTSAVDL IKERREKRAN AGKTLVKNNP KKPEMPNMLE
   241  ILKEMNSVKL RSVKRSEQDV KPKPVDATDP AALIAEALKK KFAYRYRSDS QDEVEKGIPK
   301  SESEATSERV LFGPHMLKPT GKMKALIENV SDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTFR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

liver: 33 nTPM
retina: 31 nTPM
kidney: 30 nTPM
testis: 18 nTPM
adrenal gland: 14 nTPM
stomach: 14 nTPM

Single-cell type

cardiomyocytes: 3,740 nCPM
late spermatids: 1,346 nCPM
early spermatids: 574 nCPM
myonuclei: 506 nCPM
rod photoreceptor cells: 263 nCPM
thymocytes: 258 nCPM

Immune cell

basophil: 1.3 nTPM
classical monocyte: 0.8 nTPM
myeloid DC: 0.8 nTPM
MAIT T-cell: 0.7 nTPM
memory CD4 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM

Brain region

white matter: 11 nTPM
basal ganglia: 9.9 nTPM
midbrain: 8.9 nTPM
thalamus: 8.6 nTPM
medulla oblongata: 8.3 nTPM
pons: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTFR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DIABLO

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTFR1 as an antibody target. Whether an autoantibody or antibody against MTFR1 could matter depends on whether native MTFR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTFR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTFR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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