MTFP1
Mitochondrial fission process protein 1
Also known as: HSPC242, MTFP1_HUMAN, MTP18
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UDX5
- Gene
- MTFP1
- Ensembl
- ENSG00000242114
- Chromosome
- 22
- Canonical length
- 166 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 [PubMed 15155745]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
166 residues, UniProt reviewed canonical sequence.
>Q9UDX5|MTFP1
1 MSEPQPRGAE RDLYRDTWVR YLGYANEVGE AFRSLVPAAV VWLSYGVASS YVLADAIDKG
61 KKAGEVPSPE AGRSARVTVA VVDTFVWQAL ASVAIPGFTI NRVCAASLYV LGTATRWPLA
121 VRKWTTTALG LLTIPIIIHP IDRSVDFLLD SSLRKLYPTV GKPSSSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MTFP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 3
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 52 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 52 nTPM
- kidney: 43 nTPM
- liver: 35 nTPM
- skeletal muscle: 28 nTPM
- heart muscle: 27 nTPM
- esophagus: 23 nTPM
Single-cell type
- parietal cells: 73 nCPM
- epididymal principal cells: 50 nCPM
- enteric transient amplifying cells: 49 nCPM
- enteric stem cells: 40 nCPM
- epididymal efferent duct absorptive cells: 36 nCPM
- extravillous trophoblasts: 36 nCPM
Immune cell
- MAIT T-cell: 66 nTPM
- gdT-cell: 49 nTPM
- naive CD8 T-cell: 48 nTPM
- memory CD8 T-cell: 42 nTPM
- naive CD4 T-cell: 42 nTPM
- memory CD4 T-cell: 40 nTPM
Brain region
- choroid plexus: 24 nTPM
- cerebellum: 12 nTPM
- thalamus: 11 nTPM
- hypothalamus: 9.3 nTPM
- medulla oblongata: 9 nTPM
- midbrain: 8.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.33
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.06
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Mitochondrial 18kDa protein
- Mitochondrial 18 KDa protein (MTP18)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MTFP1 as an antibody target. Whether an autoantibody or antibody against MTFP1 could matter depends on whether native MTFP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MTFP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MTFP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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