Seroatlas · Human Serome Atlas

MTFMT

Methionyl-tRNA formyltransferase, mitochondrial

Also known as: FMT_HUMAN, FMT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DP5
Gene: MTFMT
Ensembl: ENSG00000103707
Chromosome: 15
Canonical length: 389 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q96DP5|MTFMT
     1  MRVLVRRCWG PPLAHGARRG RPSPQWRALA RLGWEDCRDS RVREKPPWRV LFFGTDQFAR
    61  EALRALHAAR ENKEEELIDK LEVVTMPSPS PKGLPVKQYA VQSQLPVYEW PDVGSGEYDV
   121  GVVASFGRLL NEALILKFPY GILNVHPSCL PRWRGPAPVI HTVLHGDTVT GVTIMQIRPK
   181  RFDVGPILKQ ETVPVPPKST AKELEAVLSR LGANMLISVL KNLPESLSNG RQQPMEGATY
   241  APKISAGTSC IKWEEQTSEQ IFRLYRAIGN IIPLQTLWMA NTIKLLDLVE VNSSVLADPK
   301  LTGQALIPGS VIYHKQSQIL LVYCKDGWIG VRSVMLKKSL TATDFYNGYL HPWYQKNSQA
   361  QPSQCRFQTL RLPTKKKQKK TVAMQQCIE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTFMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 4.2 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 4.2 nTPM
cerebellum: 3.8 nTPM
liver: 3.5 nTPM
skeletal muscle: 3 nTPM
basal ganglia: 2.7 nTPM
prostate: 2.7 nTPM

Single-cell type

myonuclei: 101 nCPM
cardiomyocytes: 74 nCPM
leydig cells: 61 nCPM
brain excitatory neurons: 60 nCPM
brain inhibitory neurons: 58 nCPM
myosatellite cells: 57 nCPM

Immune cell

neutrophil: 16 nTPM
plasmacytoid DC: 9.8 nTPM
myeloid DC: 5.9 nTPM
naive CD8 T-cell: 5.4 nTPM
T-reg: 5.4 nTPM
memory CD8 T-cell: 5.1 nTPM

Brain region

choroid plexus: 11 nTPM
cerebellum: 10 nTPM
hypothalamus: 10 nTPM
basal ganglia: 8.9 nTPM
cerebral cortex: 8.9 nTPM
hippocampal formation: 8.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MTFMT.

Disease | AllUniProt

Conditions MTFMT is implicated in, by any mechanism.

Combined oxidative phosphorylation deficiency 15 (COXPD15) MIM:614947
Mitochondrial complex I deficiency, nuclear type 27 (MC1DN27) MIM:618248

Disease | GeneticClinVar

34 pathogenic / likely-pathogenic of 313 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Combined oxidative phosphorylation defect type 15
Mitochondrial complex I deficiency, nuclear type 27
MTFMT-Related Disorders
Inborn genetic diseases
MTFMT-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: -0.46
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

conversion of methionyl-tRNA to N-formyl-methionyl-tRNA

Molecular functions

methionyl-tRNA formyltransferase activity

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Formyl transferase, N-terminal
Formyl transferase, C-terminal
Formyl transferase-like, C-terminal domain superfamily
Formyl transferase, N-terminal domain superfamily
Formyl transferase
Formyl transferase, C-terminal domain
Methionyl-tRNA formyltransferase
Methionyl-tRNA formyltransferase, N-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTFMT as an antibody target. Whether an autoantibody or antibody against MTFMT could matter depends on whether native MTFMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTFMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTFMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...