Seroatlas · Human Serome Atlas

MTF1

Metal regulatory transcription factor 1

Also known as: MTF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14872
Gene: MTF1
Ensembl: ENSG00000188786
Chromosome: 1
Canonical length: 753 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

753 residues, UniProt reviewed canonical sequence.

>Q14872|MTF1
     1  MGEHSPDNNI IYFEAEEDEL TPDDKMLRFV DKNGLVPSSS GTVYDRTTVL IEQDPGTLED
    61  EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP DQIHLTINPG STPMPRNIEG
   121  ATLTLQSECP ETKRKEVKRY QCTFEGCPRT YSTAGNLRTH QKTHRGEYTF VCNQEGCGKA
   181  FLTSYSLRIH VRVHTKEKPF ECDVQGCEKA FNTLYRLKAH QRLHTGKTFN CESEGCSKYF
   241  TTLSDLRKHI RTHTGEKPFR CDHDGCGKAF AASHHLKTHV RTHTGERPFF CPSNGCEKTF
   301  STQYSLKSHM KGHDNKGHSY NALPQHNGSE DTNHSLCLSD LSLLSTDSEL RENSSTTQGQ
   361  DLSTISPAII FESMFQNSDD TAIQEDPQQT ASLTESFNGD AESVSDVPPS TGNSASLSLP
   421  LVLQPGLSEP PQPLLPASAP SAPPPAPSLG PGSQQAAFGN PPALLQPPEV PVPHSTQFAA
   481  NHQEFLPHPQ APQPIVPGLS VVAGASASAA AVASAVAAPA PPQSTTEPLP AMVQTLPLGA
   541  NSVLTNNPTI TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEKVFF
   601  TTAVPVASSP GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERASSRR KGCSSPPPPE
   661  PSPQAPDGPS LQLPAQTFSS APVPGSSSST LPSSCEQSRQ AETPSDPQTE TLSAMDVSEF
   721  LSLQSLDTPS NLIPIEALLQ GEEEMGLTSS FSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 19 nTPM
esophagus: 7.9 nTPM
testis: 6.1 nTPM
tongue: 6 nTPM
parathyroid gland: 5.7 nTPM
tonsil: 5.4 nTPM

Single-cell type

neutrophils: 795 nCPM
neutrophil progenitors: 236 nCPM
monocytes: 129 nCPM
esophageal apical cells: 118 nCPM
monocyte progenitors: 104 nCPM
esophageal suprabasal cells: 67 nCPM

Immune cell

non-classical monocyte: 6 nTPM
classical monocyte: 3.7 nTPM
neutrophil: 3.7 nTPM
intermediate monocyte: 3.5 nTPM
basophil: 2.8 nTPM
eosinophil: 2.4 nTPM

Brain region

basal ganglia: 14 nTPM
white matter: 14 nTPM
medulla oblongata: 14 nTPM
choroid plexus: 14 nTPM
midbrain: 14 nTPM
cerebral cortex: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 2.54
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTF1 as an antibody target. Whether an autoantibody or antibody against MTF1 could matter depends on whether native MTF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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