Seroatlas · Human Serome Atlas

MTERF4

Transcription termination factor 4, mitochondrial

Also known as: MGC61716, MTEF4_HUMAN, MTERFD2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6M4
Gene: MTERF4
Ensembl: ENSG00000122085
Chromosome: 2
Canonical length: 381 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Enables rRNA binding activity. Predicted to be involved in mitochondrial ribosome assembly and mitochondrial transcription. Predicted to act upstream of or within several processes, including camera-type eye development; protein targeting to mitochondrion; and ribosome assembly. Located in cytosol and mitochondrion. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>Q7Z6M4|MTERF4
     1  MAAFGRQVLD WHRLIPLTWA CMARQTPHLG EQRRTTASLL RKLTTASNGG VIEELSCVRS
    61  NNYVQEPECR RNLVQCLLEK QGTPVVQGSL ELERVMSSLL DMGFSNAHIN ELLSVRRGAS
   121  LQQLLDIISE FILLGLNPEP VCVVLKKSPQ LLKLPIMQMR KRSSYLQKLG LGEGKLKRVL
   181  YCCPEIFTMR QQDINDTVRL LKEKCLFTVQ QVTKILHSCP SVLREDLGQL EYKFQYAYFR
   241  MGIKHPDIVK SEYLQYSLTK IKQRHIYLER LGRYQTPDKK GQTQIPNPLL KDILRVSEAE
   301  FLARTACTSV EEFQVFKKLL AREEEESESS TSDDKRASLD EDEDDDDEED NDEDDNDEDD
   361  DDEDDDEAED NDEDEDDDEE E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTERF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 51 nTPM
tongue: 39 nTPM
lymph node: 36 nTPM
thyroid gland: 33 nTPM
cerebellum: 32 nTPM
prostate: 32 nTPM

Single-cell type

esophageal apical cells: 296 nCPM
fibro-adipogenic progenitors: 130 nCPM
myonuclei: 128 nCPM
myosatellite cells: 125 nCPM
decidual stromal cells: 100 nCPM
adipocytes: 98 nCPM

Immune cell

naive CD4 T-cell: 46 nTPM
naive CD8 T-cell: 37 nTPM
T-reg: 33 nTPM
memory B-cell: 33 nTPM
naive B-cell: 32 nTPM
memory CD4 T-cell: 29 nTPM

Brain region

cerebellum: 43 nTPM
white matter: 32 nTPM
cerebral cortex: 29 nTPM
hypothalamus: 28 nTPM
basal ganglia: 28 nTPM
pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTERF4 as an antibody target. Whether an autoantibody or antibody against MTERF4 could matter depends on whether native MTERF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTERF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTERF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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