Seroatlas · Human Serome Atlas

MTERF2

Transcription termination factor 2, mitochondrial

Also known as: FLJ14062, MTEF2_HUMAN, MTERFD3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q49AM1
Gene: MTERF2
Ensembl: ENSG00000120832
Chromosome: 12
Canonical length: 385 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables DNA binding activity. Predicted to be involved in termination of mitochondrial transcription. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q49AM1|MTERF2
     1  MLWKLLLRSQ SCRLCSFRKM RSPPKYRPFL ACFTYTTDKQ SSKENTRTVE KLYKCSVDIR
    61  KIRRLKGWVL LEDETYVEEI ANILQELGAD ETAVASILER CPEAIVCSPT AVNTQRKLWQ
   121  LVCKNEEELI KLIEQFPESF FTIKDQENQK LNVQFFQELG LKNVVISRLL TAAPNVFHNP
   181  VEKNKQMVRI LQESYLDVGG SEANMKVWLL KLLSQNPFIL LNSPTAIKET LEFLQEQGFT
   241  SFEILQLLSK LKGFLFQLCP RSIQNSISFS KNAFKCTDHD LKQLVLKCPA LLYYSVPVLE
   301  ERMQGLLREG ISIAQIRETP MVLELTPQIV QYRIRKLNSS GYRIKDGHLA NLNGSKKEFE
   361  ANFGKIQAKK VRPLFNPVAP LNVEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTERF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 36 nTPM
pancreas: 33 nTPM
heart muscle: 30 nTPM
thyroid gland: 29 nTPM
liver: 29 nTPM
retina: 28 nTPM

Single-cell type

oocytes: 74 nCPM
cone photoreceptor cells: 58 nCPM
late primary spermatocytes: 56 nCPM
myonuclei: 51 nCPM
epicardial cells: 48 nCPM
retinal bipolar cells: 47 nCPM

Immune cell

gdT-cell: 12 nTPM
memory CD4 T-cell: 11 nTPM
plasmacytoid DC: 11 nTPM
T-reg: 11 nTPM
MAIT T-cell: 10 nTPM
naive CD8 T-cell: 9.8 nTPM

Brain region

cerebellum: 33 nTPM
hypothalamus: 20 nTPM
cerebral cortex: 19 nTPM
thalamus: 18 nTPM
choroid plexus: 18 nTPM
basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

termination of mitochondrial transcription

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTERF2 as an antibody target. Whether an autoantibody or antibody against MTERF2 could matter depends on whether native MTERF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTERF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTERF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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