Seroatlas · Human Serome Atlas

MTERF1

Transcription termination factor 1, mitochondrial

Also known as: MTEF1_HUMAN, MTERF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99551
Gene
MTERF1
Ensembl
ENSG00000127989
Chromosome
7
Canonical length
399 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q99551|MTERF1
     1  MQSLSLGQTS ISKGLNYLTI MAPGNLWHMR NNFLFGSRCW MTRFSAENIF KSVSFRLFGV
    61  KCHNTDSEPL KNEDLLKNLL TMGVDIDMAR KRQPGVFHRM ITNEQDLKMF LLSKGASKEV
   121  IASIISRYPR AITRTPENLS KRWDLWRKIV TSDLEIVNIL ERSPESFFRS NNNLNLENNI
   181  KFLYSVGLTR KCLCRLLTNA PRTFSNSLDL NKQMVEFLQA AGLSLGHNDP ADFVRKIIFK
   241  NPFILIQSTK RVKANIEFLR STFNLNSEEL LVLICGPGAE ILDLSNDYAR RSYANIKEKL
   301  FSLGCTEEEV QKFVLSYPDV IFLAEKKFND KIDCLMEENI SISQIIENPR VLDSSISTLK
   361  SRIKELVNAG CNLSTLNITL LSWSKKRYEA KLKKLSRFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTERF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 13 nTPM
  • tonsil: 12 nTPM
  • thymus: 11 nTPM
  • liver: 11 nTPM
  • bone marrow: 9.5 nTPM
  • spleen: 9.1 nTPM

Single-cell type

  • oligodendrocytes: 174 nCPM
  • distal convoluted tubule cells: 158 nCPM
  • podocytes: 148 nCPM
  • renal connecting tubule cells: 135 nCPM
  • renal collecting duct intercalated cells: 129 nCPM
  • pituitary stem cells: 120 nCPM

Immune cell

  • basophil: 46 nTPM
  • naive CD4 T-cell: 26 nTPM
  • naive B-cell: 24 nTPM
  • memory B-cell: 22 nTPM
  • memory CD8 T-cell: 22 nTPM
  • naive CD8 T-cell: 21 nTPM

Brain region

  • white matter: 19 nTPM
  • hypothalamus: 16 nTPM
  • basal ganglia: 16 nTPM
  • pons: 16 nTPM
  • thalamus: 15 nTPM
  • cerebellum: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.26
gnomAD pLI
0
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTERF1 as an antibody target. Whether an autoantibody or antibody against MTERF1 could matter depends on whether native MTERF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTERF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTERF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MTERF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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