MTCP1
Protein p13 MTCP-1
Also known as: MTCP1_HUMAN, P13MTCP1, p8MTCP1, TCL1C
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P56278
- Gene
- MTCP1
- Ensembl
- ENSG00000214827
- Chromosome
- X
- Canonical length
- 107 aa
- Protein class
- Cancer-related genes, Disease related genes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Plasma membrane
OverviewNCBI Gene
This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the upstream 13 kDa protein that is a member of the TCL1 family. This protein may be involved in leukemogenesis. [provided by RefSeq, Mar 2009]
Canonical amino-acid sequenceUniProt
107 residues, UniProt reviewed canonical sequence.
>P56278|MTCP1
1 MAGEDVGAPP DHLWVHQEGI YRDEYQRTWV AVVEEETSFL RARVQQIQVP LGDAARPSHL
61 LTSQLPLMWQ LYPEERYMDN NSRLWQIQHH LMVRGVQELL LKLLPDDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MTCP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 5.2 nTPM
Expression across tissuesHPA
Tissue
- testis: 5.2 nTPM
- skin: 3.9 nTPM
- choroid plexus: 2.8 nTPM
- bone marrow: 2.7 nTPM
- epididymis: 2.5 nTPM
- pancreas: 2.5 nTPM
Single-cell type
- sertoli cells: 770 nCPM
- cardiomyocytes: 142 nCPM
- epicardial cells: 130 nCPM
- leydig cells: 58 nCPM
- retinal ganglion cells: 58 nCPM
- myonuclei: 55 nCPM
Immune cell
- MAIT T-cell: 0.3 nTPM
- gdT-cell: 0.2 nTPM
- memory CD4 T-cell: 0.2 nTPM
- naive CD8 T-cell: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- eosinophil: 0.1 nTPM
Brain region
- cerebellum: 3.7 nTPM
- medulla oblongata: 2.6 nTPM
- choroid plexus: 2.5 nTPM
- white matter: 2.5 nTPM
- basal ganglia: 2.4 nTPM
- cerebral cortex: 2.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.85
- gnomAD pLI
- 0.45
- gnomAD missense Z
- 1.64
- DepMap mean gene effect
- 0.2
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MTCP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MTCP1 as an antibody target. Whether an autoantibody or antibody against MTCP1 could matter depends on whether native MTCP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MTCP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MTCP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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