Seroatlas · Human Serome Atlas

MTCL3

Microtubule cross-linking factor 3

Also known as: C6orf174, dJ403A15.3, MTCL3_HUMAN, SOGA3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TF21
Gene: MTCL3
Ensembl: ENSG00000214338
Chromosome: 6
Canonical length: 947 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in regulation of autophagy. Predicted to be located in extracellular space and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

947 residues, UniProt reviewed canonical sequence.

>Q5TF21|MTCL3
     1  MSQPPIGGAA PATAAASPAA AATEARLHPE GSSRKQQRAQ SPARPRDSSL RQTIAATRSP
    61  VGAGTKLNSV RQQQLQQQQQ QGNKTGSRTG PPASIRGGGG GAEKATPLAP KGAAPGAVQP
   121  VAGAEAAPAA TLAALGGRRP GPPEEPPREL ESVPSKLGEP PPLGEGGGGG GEGGGAGGGS
   181  GEREGGAPQP PPPRGWRGKG VRAQQRGGSG GEGASPSPSS SSAGKTPGTG SRNSGSGVAG
   241  GGSGGGGSYW KEGCLQSELI QFHLKKERAA AAAAAAQMHA KNGGGSSSRS SPVSGPPAVC
   301  ETLAVASASP MAAAAEGPQQ SAEGSASGGG MQAAAPPSSQ PHPQQLQEQE EMQEEMEKLR
   361  EENETLKNEI DELRTEMDEM RDTFFEEDAC QLQEMRHELE RANKNCRILQ YRLRKAERKR
   421  LRYAQTGEID GELLRSLEQD LKVAKDVSVR LHHELENVEE KRTTTEDENE KLRQQLIEVE
   481  IAKQALQNEL EKMKELSLKR RGSKDLPKSE KKAQQTPTEE DNEDLKCQLQ FVKEEAALMR
   541  KKMAKIDKEK DRFEHELQKY RSFYGDLDSP LPKGEAGGPP STREAELKLR LRLVEEEANI
   601  LGRKIVELEV ENRGLKAELD DLRGDDFNGS ANPLMREQSE SLSELRQHLQ LVEDETELLR
   661  RNVADLEEQN KRITAELNKY KYKSGGHDSA RHHDNAKTEA LQEELKAARL QINELSGKVM
   721  QLQYENRVLM SNMQRYDLAS HLGIRGSPRD SDAESDAGKK ESDDDSRPPH RKREGPIGGE
   781  SDSEEVRNIR CLTPTRSFYP APGPWPKSFS DRQQMKDIRS EAERLGKTID RLIADTSTII
   841  TEARIYVANG DLFGLMDEED DGSRIREHEL LYRINAQMKA FRKELQTFID RLEVPKSADD
   901  RGAEEPISVS QMFQPIILLI LILVLFSSLS YTTIFKLVFL FTLFFVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTCL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 7.7 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 7.7 nTPM
retina: 3.2 nTPM
spinal cord: 2.9 nTPM
lung: 2.2 nTPM
stomach: 2.1 nTPM
adrenal gland: 1.5 nTPM

Single-cell type

brain excitatory neurons: 58 nCPM
other brain neurons: 57 nCPM
brain inhibitory neurons: 53 nCPM
bergmann glia: 36 nCPM
oligodendrocyte progenitor cells: 36 nCPM
oligodendrocytes: 21 nCPM

Immune cell

memory CD4 T-cell: 0.6 nTPM
T-reg: 0.4 nTPM
memory CD8 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

cerebral cortex: 57 nTPM
white matter: 54 nTPM
cerebellum: 51 nTPM
thalamus: 51 nTPM
hippocampal formation: 47 nTPM
medulla oblongata: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.68

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of autophagy

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTCL3 as an antibody target. Whether an autoantibody or antibody against MTCL3 could matter depends on whether native MTCL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTCL3 is annotated as secreted, so native MTCL3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MTCL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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