Seroatlas · Human Serome Atlas

MTBP

Mdm2-binding protein

Also known as: MTBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DY7
Gene: MTBP
Ensembl: ENSG00000172167
Chromosome: 8
Canonical length: 904 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

904 residues, UniProt reviewed canonical sequence.

>Q96DY7|MTBP
     1  MDRYLLLVIW GEGKFPSAAS REAEHGPEVS SGEGTENQPD FTAANVYHLL KRSISASINP
    61  EDSTFPACSV GGIPGSKKWF FAVQAIYGFY QFCSSDWQEI HFDTEKDKIE DVLQTNIEEC
   121  LGAVECFEEE DSNSRESLSL ADLYEEAAEN LHQLSDKLPA PGRAMVDIIL LLSDKDPPKL
   181  KDYLPTVGAL KHLREWYSAK ITIAGNHCEI NCQKIAEYLS ANVVSLEDLR NVIDSKELWR
   241  GKIQIWERKF GFEISFPEFC LKGVTLKNFS TSNLNTDFLA KKIIPSKDKN ILPKVFHYYG
   301  PALEFVQMIK LSDLPSCYMS DIEFELGLTN STKQNSVLLL EQISSLCSKV GALFVLPCTI
   361  SNILIPPPNQ LSSRKWKEYI AKKPKTISVP DVEVKGECSS YYLLLQGNGN RRCKATLIHS
   421  ANQINGSFAL NLIHGKMKTK TEEAKLSFPF DLLSLPHFSG EQIVQREKQL ANVQVLALEE
   481  CLKRRKLAKQ PETVSVAELK SLLVLTRKHF LDYFDAVIPK MILRKMDKIK TFNILNDFSP
   541  VEPNSSSLME TNPLEWPERH VLQNLETFEK TKQKMRTGSL PHSSEQLLGH KEGPRDSITL
   601  LDAKELLKYF TSDGLPIGDL QPLPIQKGEK TFVLTPELSP GKLQVLPFEK ASVCHYHGIE
   661  YCLDDRKALE RDGGFSELQS RLIRYETQTT CTRESFPVPT VLSPLPSPVV SSDPGSVPDG
   721  EVLQNELRTE VSRLKRRSKD LNCLYPRKRL VKSESSESLL SQTTGNSNHY HHHVTSRKPQ
   781  TERSLPVTCP LVPIPSCETP KLATKTSSGQ KSMHESKTSR QIKESRSQKH TRILKEVVTE
   841  TLKKHSITET HECFTACSQR LFEISKFYLK DLKTSRGLFE EMKKTANNNA VQVIDWVLEK
   901  TSKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 6.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 6.1 nTPM
testis: 4.6 nTPM
thymus: 4.3 nTPM
lymph node: 4 nTPM
retina: 3.9 nTPM
bone marrow: 3.8 nTPM

Single-cell type

early primary spermatocytes: 112 nCPM
adipocytes: 67 nCPM
erythrocyte progenitors: 57 nCPM
adrenal medulla cells: 53 nCPM
salivary ionocytes: 46 nCPM
monocyte progenitors: 45 nCPM

Immune cell

naive CD4 T-cell: 0.8 nTPM
memory B-cell: 0.7 nTPM
memory CD8 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM
T-reg: 0.7 nTPM
intermediate monocyte: 0.6 nTPM

Brain region

cerebellum: 7.5 nTPM
cerebral cortex: 3.5 nTPM
white matter: 2.9 nTPM
pons: 2.6 nTPM
thalamus: 2.2 nTPM
midbrain: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: -1.68
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

MDN2-binding protein, C-terminal domain
MDM2-binding protein, central domain
MDM2-binding protein, N-terminal domain
MDN2-binding protein
MDM2-binding
MDM2-binding
MDM2-binding

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MDM2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTBP as an antibody target. Whether an autoantibody or antibody against MTBP could matter depends on whether native MTBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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