Seroatlas · Human Serome Atlas

MTARC2

Mitochondrial amidoxime reducing component 2

Also known as: FLJ20605, MARC2, MARC2_HUMAN, MOSC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969Z3
Gene: MTARC2
Ensembl: ENSG00000117791
Chromosome: 1
Canonical length: 335 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q969Z3|MTARC2
     1  MGASSSSALA RLGLPARPWP RWLGVAALGL AAVALGTVAW RRAWPRRRRR LQQVGTVAKL
    61  WIYPVKSCKG VPVSEAECTA MGLRSGNLRD RFWLVIKEDG HMVTARQEPR LVLISIIYEN
   121  NCLIFRAPDM DQLVLPSKQP SSNKLHNCRI FGLDIKGRDC GNEAAKWFTN FLKTEAYRLV
   181  QFETNMKGRT SRKLLPTLDQ NFQVAYPDYC PLLIMTDASL VDLNTRMEKK MKMENFRPNI
   241  VVTGCDAFEE DTWDELLIGS VEVKKVMACP RCILTTVDPD TGVIDRKQPL DTLKSYRLCD
   301  PSERELYKLS PLFGIYYSVE KIGSLRVGDP VYRMV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTARC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 209 nTPM

Expression across tissuesHPA

Tissue

liver: 209 nTPM
kidney: 123 nTPM
parathyroid gland: 117 nTPM
choroid plexus: 83 nTPM
duodenum: 56 nTPM
small intestine: 55 nTPM

Single-cell type

choroid plexus epithelial cells: 267 nCPM
proximal tubule cells: 228 nCPM
hepatocytes: 155 nCPM
sertoli cells: 131 nCPM
enterocytes: 115 nCPM
pituitary stem cells: 103 nCPM

Immune cell

basophil: 14 nTPM
memory B-cell: 2.2 nTPM
naive B-cell: 0.9 nTPM
classical monocyte: 0.1 nTPM
total PBMC: 0.1 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 109 nTPM
cerebral cortex: 21 nTPM
thalamus: 20 nTPM
midbrain: 20 nTPM
basal ganglia: 19 nTPM
hippocampal formation: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTARC2 as an antibody target. Whether an autoantibody or antibody against MTARC2 could matter depends on whether native MTARC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTARC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTARC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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