Seroatlas · Human Serome Atlas

MTARC1

Mitochondrial amidoxime-reducing component 1

Also known as: FLJ22390, MARC1, MARC1_HUMAN, MOSC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VT66
Gene: MTARC1
Ensembl: ENSG00000186205
Chromosome: 1
Canonical length: 337 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Contributes to nitrite reductase (NO-forming) activity. Involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Part of nitric-oxide synthase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q5VT66|MTARC1
     1  MGAAGSSALA RFVLLAQSRP GWLGVAALGL TAVALGAVAW RRAWPTRRRR LLQQVGTVAQ
    61  LWIYPVKSCK GVPVSEAECT AMGLRSGNLR DRFWLVINQE GNMVTARQEP RLVLISLTCD
   121  GDTLTLSAAY TKDLLLPIKT PTTNAVHKCR VHGLEIEGRD CGEATAQWIT SFLKSQPYRL
   181  VHFEPHMRPR RPHQIADLFR PKDQIAYSDT SPFLILSEAS LADLNSRLEK KVKATNFRPN
   241  IVISGCDVYA EDSWDELLIG DVELKRVMAC SRCILTTVDP DTGVMSRKEP LETLKSYRQC
   301  DPSERKLYGK SPLFGQYFVL ENPGTIKVGD PVYLLGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTARC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 161 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 161 nTPM
liver: 80 nTPM
breast: 75 nTPM
thyroid gland: 52 nTPM
prostate: 32 nTPM
salivary gland: 28 nTPM

Single-cell type

proximal tubule cells: 31 nCPM
loop of henle epithelial cells: 18 nCPM
renal collecting duct principal cells: 17 nCPM
renal connecting tubule cells: 12 nCPM
distal convoluted tubule cells: 12 nCPM
tuft cells: 12 nCPM

Immune cell

neutrophil: 47 nTPM
classical monocyte: 37 nTPM
basophil: 31 nTPM
eosinophil: 14 nTPM
total PBMC: 11 nTPM
intermediate monocyte: 2.8 nTPM

Brain region

hypothalamus: 22 nTPM
midbrain: 18 nTPM
thalamus: 17 nTPM
medulla oblongata: 15 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTARC1 as an antibody target. Whether an autoantibody or antibody against MTARC1 could matter depends on whether native MTARC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTARC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTARC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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