Seroatlas · Human Serome Atlas

MT3

Metallothionein-3

Also known as: GIF, MT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P25713
Gene
MT3
Ensembl
ENSG00000087250
Chromosome
16
Canonical length
68 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017]

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>P25713|MT3
     1  MDPETCPCPS GGSCTCADSC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV CKGGEAAEAE
    61  AEKCSCCQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
7,006 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 7,006 nTPM
  • basal ganglia: 5,987 nTPM
  • cerebral cortex: 5,763 nTPM
  • midbrain: 5,609 nTPM
  • hippocampal formation: 4,346 nTPM
  • hypothalamus: 3,263 nTPM

Single-cell type

  • bergmann glia: 517 nCPM
  • astrocytes: 463 nCPM
  • schwann cells: 301 nCPM
  • müller glia: 275 nCPM
  • oligodendrocyte progenitor cells: 210 nCPM
  • epididymal efferent duct absorptive cells: 93 nCPM

Immune cell

  • naive CD8 T-cell: 5 nTPM
  • naive CD4 T-cell: 1.2 nTPM
  • gdT-cell: 0.8 nTPM
  • memory CD4 T-cell: 0.5 nTPM
  • total PBMC: 0.5 nTPM
  • memory CD8 T-cell: 0.4 nTPM

Brain region

  • thalamus: 2,059 nTPM
  • basal ganglia: 1,831 nTPM
  • cerebral cortex: 1,670 nTPM
  • cerebellum: 1,614 nTPM
  • amygdala: 1,581 nTPM
  • white matter: 1,467 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0.06
gnomAD missense Z
0.66
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT3 as an antibody target. Whether an autoantibody or antibody against MT3 could matter depends on whether native MT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT3 is annotated as secreted, so native MT3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MT3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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