Seroatlas · Human Serome Atlas

MT1M

Metallothionein-1M

Also known as: MT1, MT1K, MT1M_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N339
Gene
MT1M
Ensembl
ENSG00000205364
Chromosome
16
Canonical length
61 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

61 residues, UniProt reviewed canonical sequence.

>Q8N339|MT1M
     1  MDPNCSCTTG VSCACTGSCT CKECKCTSCK KSCCSCCPVG CAKCAHGCVC KGTLENCSCC
    61  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT1M can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
1,517 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,517 nTPM
  • adipose tissue: 989 nTPM
  • midbrain: 577 nTPM
  • breast: 389 nTPM
  • basal ganglia: 362 nTPM
  • cerebral cortex: 330 nTPM

Single-cell type

  • endometrial luminal cells: 2,055 nCPM
  • gastric chief cells: 1,459 nCPM
  • hepatocytes: 1,383 nCPM
  • vascular smooth muscle cells: 1,147 nCPM
  • colonocytes: 900 nCPM
  • enterocytes: 815 nCPM

Immune cell

  • neutrophil: 0.9 nTPM
  • basophil: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • thalamus: 151 nTPM
  • cerebellum: 136 nTPM
  • medulla oblongata: 122 nTPM
  • basal ganglia: 119 nTPM
  • pons: 112 nTPM
  • midbrain: 109 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0
gnomAD missense Z
-1.09
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT1M as an antibody target. Whether an autoantibody or antibody against MT1M could matter depends on whether native MT1M is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT1M is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MT1M as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MT1M. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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