MT1L
Metallothionein-1L
Also known as: MT1L_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for MT1L in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
61 residues, UniProt reviewed canonical sequence.
>Q93083|MT1L
1 MDPNCSCATG GSCSCASSCK CKECKCTSCK KSCCSCCPMG CAKCAQGCVC KGASEKCSCC
61 ALocalizationUniProt · AlphaFold · HPA
Whether an antibody against MT1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to cadmium ion
- cellular response to copper ion
- cellular response to zinc ion
- detoxification of copper ion
- intracellular zinc ion homeostasis
- negative regulation of growth
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MT1L as an antibody target. Whether an autoantibody or antibody against MT1L could matter depends on whether native MT1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MT1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MT1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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