Seroatlas · Human Serome Atlas

MT1E

Metallothionein-1E

Also known as: MT1, MT1E_HUMAN, MTD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04732
Gene
MT1E
Ensembl
ENSG00000169715
Chromosome
16
Canonical length
61 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

61 residues, UniProt reviewed canonical sequence.

>P04732|MT1E
     1  MDPNCSCATG GSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCVC KGASEKCSCC
    61  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT1E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
1,743 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,743 nTPM
  • adipose tissue: 902 nTPM
  • midbrain: 767 nTPM
  • stomach: 549 nTPM
  • pancreas: 525 nTPM
  • kidney: 507 nTPM

Single-cell type

  • gastric chief cells: 6,250 nCPM
  • enterocytes: 4,972 nCPM
  • hepatocytes: 3,962 nCPM
  • colonocytes: 3,163 nCPM
  • epididymal efferent duct absorptive cells: 3,075 nCPM
  • epididymal efferent duct ciliated cells: 2,800 nCPM

Immune cell

  • T-reg: 21 nTPM
  • memory CD8 T-cell: 21 nTPM
  • naive CD8 T-cell: 15 nTPM
  • gdT-cell: 15 nTPM
  • memory CD4 T-cell: 8.5 nTPM
  • myeloid DC: 5.9 nTPM

Brain region

  • thalamus: 213 nTPM
  • medulla oblongata: 199 nTPM
  • cerebellum: 193 nTPM
  • midbrain: 190 nTPM
  • pons: 184 nTPM
  • hypothalamus: 161 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0.03
gnomAD missense Z
-0.34
DepMap mean gene effect
-0.48
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT1E as an antibody target. Whether an autoantibody or antibody against MT1E could matter depends on whether native MT1E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT1E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MT1E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MT1E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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