Seroatlas · Human Serome Atlas

MT1B

Metallothionein-1B

Also known as: MT1, MT1B_HUMAN, MT1Q

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07438
Gene
MT1B
Ensembl
ENSG00000169688
Chromosome
16
Canonical length
61 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

61 residues, UniProt reviewed canonical sequence.

>P07438|MT1B
     1  MDPNCSCTTG GSCACAGSCK CKECKCTSCK KCCCSCCPVG CAKCAQGCVC KGSSEKCRCC
    61  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • liver: 20 nTPM
  • duodenum: 1.1 nTPM
  • adipose tissue: 0.9 nTPM
  • appendix: 0.3 nTPM
  • esophagus: 0.3 nTPM
  • prostate: 0.3 nTPM

Single-cell type

  • hepatocytes: 15 nCPM
  • neutrophils: 8.5 nCPM
  • extravillous trophoblasts: 5.5 nCPM
  • enterocytes: 3.4 nCPM
  • epididymal efferent duct ciliated cells: 2.9 nCPM
  • endometrial luminal cells: 1.8 nCPM

Immune cell

  • memory CD8 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • midbrain: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0.01
gnomAD missense Z
0.02
DepMap mean gene effect
-0.42
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT1B as an antibody target. Whether an autoantibody or antibody against MT1B could matter depends on whether native MT1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MT1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MT1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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