Seroatlas · Human Serome Atlas

MT1A

Metallothionein-1A

Also known as: MT1, MT1A_HUMAN, MT1S

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P04731
Gene: MT1A
Ensembl: ENSG00000205362
Chromosome: 16
Canonical length: 61 aa
Protein class: Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017]

Canonical amino-acid sequenceUniProt

61 residues, UniProt reviewed canonical sequence.

>P04731|MT1A
     1  MDPNCSCATG GSCTCTGSCK CKECKCTSCK KSCCSCCPMS CAKCAQGCIC KGASEKCSCC
    61  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 476 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 476 nTPM
liver: 401 nTPM
breast: 201 nTPM
blood vessel: 149 nTPM
lung: 121 nTPM
skeletal muscle: 94 nTPM

Single-cell type

vascular smooth muscle cells: 1,000 nCPM
pericytes: 540 nCPM
hepatocytes: 312 nCPM
epididymal efferent duct ciliated cells: 257 nCPM
epididymal efferent duct absorptive cells: 129 nCPM
myosatellite cells: 111 nCPM

Immune cell

T-reg: 0.6 nTPM
memory CD8 T-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

basal ganglia: 10 nTPM
pons: 8.9 nTPM
spinal cord: 8.9 nTPM
medulla oblongata: 7.8 nTPM
thalamus: 7.7 nTPM
midbrain: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: 0.08
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT1A as an antibody target. Whether an autoantibody or antibody against MT1A could matter depends on whether native MT1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MT1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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