MT-RNR2
Humanin
Also known as: HUNIN_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for MT-RNR2 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
24 residues, UniProt reviewed canonical sequence.
>Q8IVG9|MT-RNR2
1 MAPRGFSCLL LLTSEIDLPV KRRALocalizationUniProt · AlphaFold · HPA
Whether an antibody against MT-RNR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about MT-RNR2.
Disease | GeneticClinVar
2 pathogenic / likely-pathogenic of 22 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Chloramphenicol resistance
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MT-RNR2 as an antibody target. Whether an autoantibody or antibody against MT-RNR2 could matter depends on whether native MT-RNR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MT-RNR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MT-RNR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...