MT-RNR1
Mitochondrial-derived peptide MOTS-c
Also known as: MOTSC_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- A0A0C5B5G6
- Gene
- MT-RNR1
- Canonical length
- 16 aa
OverviewNCBI Gene
No narrative summary is available for MT-RNR1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
16 residues, UniProt reviewed canonical sequence.
>A0A0C5B5G6|MT-RNR1
1 MRWQEMGYIF YPRKLRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MT-RNR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.81
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about MT-RNR1.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 80 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
OntologyGO
Biological processes
- activation of protein kinase activity
- osteoblast differentiation
- osteoblast proliferation
- positive regulation of protein serine/threonine kinase activity
- regulation of transcription by RNA polymerase II
- skeletal muscle tissue growth
- negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
- purine-containing compound biosynthetic process
- regulation of carbohydrate utilization
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Mitochondrial-derived peptide MOTS-c
- Mitochondrial-derived peptide MOTS-c
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MT-RNR1 as an antibody target. Whether an autoantibody or antibody against MT-RNR1 could matter depends on whether native MT-RNR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MT-RNR1 is annotated as secreted, so native MT-RNR1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label MT-RNR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...