Seroatlas · Human Serome Atlas

MT-ND6

NADH-ubiquinone oxidoreductase chain 6

Also known as: MTND6, NAD6, ND6, NU6M_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P03923
Gene: MT-ND6
Ensembl: ENSG00000198695
Chromosome: MT
Canonical length: 174 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Implicated in Leber hereditary optic neuropathy; Leigh disease; and spinal muscular atrophy with lower extremity predominant 2B. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

174 residues, UniProt reviewed canonical sequence.

>P03923|MT-ND6
     1  MMYALFLLSV GLVMGFVGFS SKPSPIYGGL VLIVSGVVGC VIILNFGGGY MGLMVFLIYL
    61  GGMMVVFGYT TAMAIEEYPE AWGSGVEVLV SVLVGLAMEV GLVLWVKEYD GVVVVVNFNS
   121  VGSWMIYEGE GSGLIREDPI GAGALYDYGR WLVVVTGWTL FVGVYIVIEI ARGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT-ND6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 54,271 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 54,271 nTPM
heart muscle: 33,513 nTPM
basal ganglia: 25,107 nTPM
hippocampal formation: 17,731 nTPM
amygdala: 16,788 nTPM
hypothalamus: 15,163 nTPM

Single-cell type

hepatocytes: 560 nCPM
retinal horizontal cells: 407 nCPM
retinal bipolar cells: 385 nCPM
rod photoreceptor cells: 308 nCPM
thymic myoid cells: 276 nCPM
retinal pigment epithelial cells: 269 nCPM

Immune cell

basophil: 2,109 nTPM
classical monocyte: 1,096 nTPM
memory B-cell: 1,052 nTPM
naive B-cell: 1,020 nTPM
non-classical monocyte: 970 nTPM
intermediate monocyte: 884 nTPM

Brain region

cerebral cortex: 49,030 nTPM
pons: 45,443 nTPM
medulla oblongata: 44,434 nTPM
choroid plexus: 42,086 nTPM
midbrain: 40,133 nTPM
thalamus: 32,691 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MT-ND6.

Disease | AllUniProt

Conditions MT-ND6 is implicated in, by any mechanism.

Leber hereditary optic neuropathy (LHON) MIM:535000
Leber hereditary optic neuropathy with dystonia (LDYT) MIM:500001
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS) MIM:540000
Leigh syndrome (LS) MIM:256000

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 115 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

OntologyGO

Biological processes

Molecular functions

NADH dehydrogenase (ubiquinone) activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

NADH:ubiquinone/plastoquinone oxidoreductase, chain 6
Complex I Subunit 6
NADH-ubiquinone/plastoquinone oxidoreductase chain 6

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT-ND6 as an antibody target. Whether an autoantibody or antibody against MT-ND6 could matter depends on whether native MT-ND6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT-ND6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MT-ND6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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