MT-ND4L
NADH-ubiquinone oxidoreductase chain 4L
Also known as: MTND4L, NAD4L, ND4L, NU4LM_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P03901
- Gene
- MT-ND4L
- Ensembl
- ENSG00000212907
- Chromosome
- MT
- Canonical length
- 98 aa
- Protein class
- Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins
- Subcellular location
- Centrosome,Mitochondria,Cytosol
OverviewNCBI Gene
Enables NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in Leber hereditary optic neuropathy and diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
98 residues, UniProt reviewed canonical sequence.
>P03901|MT-ND4L
1 MPLIYMNIML AFTISLLGML VYRSHLMSSL LCLEGMMLSL FIMATLMTLN THSLLANIVP
61 IAMLVFAACE AAVGLALLVS ISNTYGLDYV HNLNLLQCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MT-ND4L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 3
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 149,995 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 149,995 nTPM
- tongue: 96,029 nTPM
- liver: 75,489 nTPM
- basal ganglia: 63,687 nTPM
- hippocampal formation: 59,537 nTPM
- skeletal muscle: 55,362 nTPM
Single-cell type
- hepatocytes: 3,652 nCPM
- urothelial cells: 1,474 nCPM
- pancreatic acinar cells: 1,108 nCPM
- enterocytes: 1,095 nCPM
- breast myoepithelial cells: 1,076 nCPM
- colonocytes: 1,076 nCPM
Immune cell
- basophil: 16,397 nTPM
- eosinophil: 8,356 nTPM
- naive B-cell: 4,642 nTPM
- classical monocyte: 4,363 nTPM
- memory B-cell: 4,254 nTPM
- naive CD8 T-cell: 4,023 nTPM
Brain region
- cerebral cortex: 57,554 nTPM
- choroid plexus: 44,688 nTPM
- medulla oblongata: 41,156 nTPM
- hypothalamus: 37,044 nTPM
- pons: 35,116 nTPM
- midbrain: 32,973 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about MT-ND4L.
Disease | AllUniProt
Conditions MT-ND4L is implicated in, by any mechanism.
- Leber hereditary optic neuropathy (LHON) MIM:535000
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 33 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
OntologyGO
Biological processes
- aerobic respiration
- mitochondrial electron transport, NADH to ubiquinone
- proton motive force-driven mitochondrial ATP synthesis
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- NADH-ubiquinone oxidoreductase chain 4L/K
- NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like
- NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MT-ND4L as an antibody target. Whether an autoantibody or antibody against MT-ND4L could matter depends on whether native MT-ND4L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MT-ND4L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MT-ND4L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...