Seroatlas · Human Serome Atlas

MSTO1

Protein misato homolog 1

Also known as: FLJ10504, LST005, misato, MST, MSTO1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BUK6
Gene
MSTO1
Ensembl
ENSG00000125459
Chromosome
1
Canonical length
570 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Involved in mitochondrion distribution; mitochondrion organization; and positive regulation of mitochondrial fusion. Located in mitochondrial outer membrane. Is active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q9BUK6|MSTO1
     1  MAGGAREVLT LQLGHFAGFV GAHWWNQQDA ALGRATDSKE PPGELCPDVL YRTGRTLHGQ
    61  ETYTPRLILM DLKGSLSSLK EEGGLYRDKQ LDAAIAWQGK LTTHKEELYP KNPYLQDFLS
   121  AEGVLSSDGV WRVKSIPNGK GSSPLPTATT PKPLIPTEAS IRVWSDFLRV HLHPRSICMI
   181  QKYNHDGEAG RLEAFGQGES VLKEPKYQEE LEDRLHFYVE ECDYLQGFQI LCDLHDGFSG
   241  VGAKAAELLQ DEYSGRGIIT WGLLPGPYHR GEAQRNIYRL LNTAFGLVHL TAHSSLVCPL
   301  SLGGSLGLRP EPPVSFPYLH YDATLPFHCS AILATALDTV TVPYRLCSSP VSMVHLADML
   361  SFCGKKVVTA GAIIPFPLAP GQSLPDSLMQ FGGATPWTPL SACGEPSGTR CFAQSVVLRG
   421  IDRACHTSQL TPGTPPPSAL HACTTGEEIL AQYLQQQQPG VMSSSHLLLT PCRVAPPYPH
   481  LFSSCSPPGM VLDGSPKGAA VESIPVFGAL CSSSSLHQTL EALARDLTKL DLRRWASFMD
   541  AGVEHDDVAE LLQELQSLAQ CYQGGDSLVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSTO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • liver: 31 nTPM
  • testis: 25 nTPM
  • pancreas: 24 nTPM
  • pituitary gland: 24 nTPM
  • spleen: 21 nTPM
  • prostate: 20 nTPM

Single-cell type

  • late spermatids: 424 nCPM
  • early spermatids: 94 nCPM
  • myonuclei: 37 nCPM
  • tuft cells: 35 nCPM
  • respiratory ciliated cells: 33 nCPM
  • rod photoreceptor cells: 33 nCPM

Immune cell

  • MAIT T-cell: 12 nTPM
  • gdT-cell: 11 nTPM
  • naive CD4 T-cell: 11 nTPM
  • memory CD4 T-cell: 10 nTPM
  • NK-cell: 10 nTPM
  • memory CD8 T-cell: 9.5 nTPM

Brain region

  • pons: 17 nTPM
  • medulla oblongata: 17 nTPM
  • thalamus: 16 nTPM
  • midbrain: 15 nTPM
  • cerebral cortex: 14 nTPM
  • cerebellum: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MSTO1.

Disease | AllUniProt

Conditions MSTO1 is implicated in, by any mechanism.

  • Myopathy, mitochondrial, and ataxia (MMYAT) MIM:617675

Disease | GeneticClinVar

18 pathogenic / likely-pathogenic of 230 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
-0.02
DepMap mean gene effect
-0.88
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSTO1 as an antibody target. Whether an autoantibody or antibody against MSTO1 could matter depends on whether native MSTO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSTO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSTO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MSTO1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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