Seroatlas · Human Serome Atlas

MST1L

Putative macrophage stimulating 1-like protein

Also known as: MST1L_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TV78
Gene: MST1L
Canonical length: 715 aa

OverviewNCBI Gene

No narrative summary is available for MST1L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

715 residues, UniProt reviewed canonical sequence.

>Q2TV78|MST1L
     1  MAPAPVTLLA PGAASSMSCS QPGQRSPSND FQVLRGTELQ HLLHAVVPGP WQEDVADAEE
    61  CAGRCGPLMD CWAFHYNVSS HGCQLLPWTQ HSPHSRLWHS GRCDLFQEKG EWGYMPTLRN
   121  GLEENFCRNP DGDPGGPWCH TTDPAVRFQS CSIKSCRVAA CVWCNGEEYR GAVDRTESGR
   181  ECQRWDLQHP HQHPFEPGKF LDQGLDDNYC RNPDGSERPW CYTTDPQIER EFCDLPRCGS
   241  EAQPRQEATS VSCFRGKGEG YRGTANTTTA AYLASVGTRK SHISTDLRQK NTRASEVGGG
   301  AGVGTCCCGD LRENFCWNLD GSEAPWCFTL RPGTRVGFCY QIRRCTDDVR PQDCYHGAGE
   361  QYRGTVSKTR KGVQCQRWSA ETPHKLQALT LGRHALMSGT RAWKWLRLPC HDFAPAPASV
   421  HIYLRTACTT GGELLPDPDG DSHGPWCYTM DPRTPFDYCA LRRCDQVQFE KCGKRVDRLD
   481  QRRSKLRVAG GHPGNSPWTV SLRNRQGQHF CAGSLVKEQW ILTARQCFSS CHMPLTGYEV
   541  WLGTLFQNPQ HGEPGLQRVP VAKMLCGPSG SQLVLLKLER SVTLNQRVAL ICLPPEWYVV
   601  PPGTKCEIAG WGETKGTGND TVLNVALLNV ISNQECNIKH RGHVRESEMC TEGLLAPVGA
   661  CEGDYGGPLA CFTHNCWVLK GIRIPNRVCT RSRWPAVFTR VSVFVDWIHK VMRLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MST1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MST1L as an antibody target. Whether an autoantibody or antibody against MST1L could matter depends on whether native MST1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MST1L is annotated as secreted, so native MST1L circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MST1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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