Seroatlas · Human Serome Atlas

MST1

Hepatocyte growth factor-like protein

Also known as: HGFL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P26927
Gene: MST1
Canonical length: 711 aa
Protein class: Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for MST1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

711 residues, UniProt reviewed canonical sequence.

>P26927|MST1
     1  MGWLPLLLLL TQCLGVPGQR SPLNDFQVLR GTELQHLLHA VVPGPWQEDV ADAEECAGRC
    61  GPLMDCRAFH YNVSSHGCQL LPWTQHSPHT RLRRSGRCDL FQKKDYVRTC IMNNGVGYRG
   121  TMATTVGGLP CQAWSHKFPN DHKYTPTLRN GLEENFCRNP DGDPGGPWCY TTDPAVRFQS
   181  CGIKSCREAA CVWCNGEEYR GAVDRTESGR ECQRWDLQHP HQHPFEPGKF LDQGLDDNYC
   241  RNPDGSERPW CYTTDPQIER EFCDLPRCGS EAQPRQEATT VSCFRGKGEG YRGTANTTTA
   301  GVPCQRWDAQ IPHQHRFTPE KYACKDLREN FCRNPDGSEA PWCFTLRPGM RAAFCYQIRR
   361  CTDDVRPQDC YHGAGEQYRG TVSKTRKGVQ CQRWSAETPH KPQFTFTSEP HAQLEENFCR
   421  NPDGDSHGPW CYTMDPRTPF DYCALRRCAD DQPPSILDPP DQVQFEKCGK RVDRLDQRRS
   481  KLRVVGGHPG NSPWTVSLRN RQGQHFCGGS LVKEQWILTA RQCFSSCHMP LTGYEVWLGT
   541  LFQNPQHGEP SLQRVPVAKM VCGPSGSQLV LLKLERSVTL NQRVALICLP PEWYVVPPGT
   601  KCEIAGWGET KGTGNDTVLN VALLNVISNQ ECNIKHRGRV RESEMCTEGL LAPVGACEGD
   661  YGGPLACFTH NCWVLEGIII PNRVCARSRW PAVFTRVSVF VDWIHKVMRL G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MST1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 864 nTPM

Expression across tissuesHPA

Tissue

liver: 864 nTPM
kidney: 91 nTPM
duodenum: 40 nTPM
testis: 37 nTPM
thyroid gland: 36 nTPM
pituitary gland: 30 nTPM

Single-cell type

hepatocytes: 359 nCPM
proximal tubule cells: 79 nCPM
paneth cells: 54 nCPM
enterocytes: 47 nCPM
mesothelial cells: 47 nCPM
epididymal efferent duct absorptive cells: 29 nCPM

Immune cell

gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 5.4 nTPM
cerebral cortex: 4.7 nTPM
medulla oblongata: 4.7 nTPM
midbrain: 4.7 nTPM
pons: 4.5 nTPM
white matter: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: -0.53
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of gluconeogenesis
proteolysis
regulation of receptor signaling pathway via JAK-STAT
regulation of cAMP-dependent protein kinase activity

Molecular functions

receptor tyrosine kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MST1 as an antibody target. Whether an autoantibody or antibody against MST1 could matter depends on whether native MST1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MST1 is annotated as secreted, so native MST1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MST1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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