Seroatlas · Human Serome Atlas

MSS51

Putative protein MSS51 homolog, mitochondrial

Also known as: FLJ39565, MSS51_HUMAN, ZMYND17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4VC12
Gene: MSS51
Ensembl: ENSG00000166343
Chromosome: 10
Canonical length: 460 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

460 residues, UniProt reviewed canonical sequence.

>Q4VC12|MSS51
     1  MAPRSRRRRH KKPPSSVAPI IMAPTTIVTP VPLTPSKPGP SIDTLGFFSL DDNVPGLSQL
    61  ILQKLNMKSY EEYKLVVDGG TPVSGFGFRC PQEMFQRMED TFRFCAHCRA LPSGLSDSKV
   121  LRHCKRCRNV YYCGPECQKS DWPAHRRVCQ ELRLVAVDRL MEWLLVTGDF VLPSGPWPWP
   181  PEAVQDWDSW FSMKGLHLDA TLDAVLVSHA VTTLWASVGR PRPDPDVLQG SLKRLLTDVL
   241  SRPLTLGLGL RALGIDVRRT GGSTVHVVGA SHVETFLTRP GDYDELGYMF PGHLGLRVVM
   301  VGVDVATGFS QSTSTSPLEP GTIQLSAHRG LYHDFWEEQV ETGQTHHPDL VAAFHPGFHS
   361  SPDLMEAWLP TLLLLRDYKI PTLITVYSHQ ELVSSLQILV ELDTHITAFG SNPFMSLKPE
   421  QVYSSPNKQP VYCSAYYIMF LGSSCQLDNR QLEEKVDGGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSS51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 245 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 245 nTPM
parathyroid gland: 53 nTPM
heart muscle: 10 nTPM
tongue: 5.5 nTPM
cerebellum: 5.4 nTPM
spleen: 3.7 nTPM

Single-cell type

myonuclei: 121 nCPM
retinal ganglion cells: 16 nCPM
fibro-adipogenic progenitors: 15 nCPM
brain excitatory neurons: 15 nCPM
adrenal cortex cells: 14 nCPM
cardiomyocytes: 12 nCPM

Immune cell

gdT-cell: 0.2 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 14 nTPM
cerebral cortex: 8.9 nTPM
choroid plexus: 8.2 nTPM
basal ganglia: 8.1 nTPM
white matter: 7.6 nTPM
amygdala: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

Zinc finger, MYND-type
Mitochondrial splicing suppressor 51-like, C-terminal domain
MYND finger
MSS51 C-terminal domain
Mitochondrial gene expression regulator

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSS51 as an antibody target. Whether an autoantibody or antibody against MSS51 could matter depends on whether native MSS51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSS51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSS51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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