Seroatlas · Human Serome Atlas

MSRB2

Methionine-R-sulfoxide reductase B2, mitochondrial

Also known as: CBS-1, CBS1, CGI-131, MSRB, MSRB2_HUMAN, PILB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3D2
Gene: MSRB2
Ensembl: ENSG00000148450
Chromosome: 10
Canonical length: 182 aa
Protein class: Enzymes, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization and protein repair. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q9Y3D2|MSRB2
     1  MARLLWLLRG LTLGTAPRRA VRGQAGGGGP GTGPGLGEAG SLATCELPLA KSEWQKKLTP
    61  EQFYVTREKG TEPPFSGIYL NNKEAGMYHC VCCDSPLFSS EKKYCSGTGW PSFSEAHGTS
   121  GSDESHTGIL RRLDTSLGSA RTEVVCKQCE AHLGHVFPDG PGPNGQRFCI NSVALKFKPR
   181  KH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSRB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 61 nTPM
tongue: 48 nTPM
skeletal muscle: 40 nTPM
liver: 29 nTPM
choroid plexus: 27 nTPM
amygdala: 27 nTPM

Single-cell type

hepatocytes: 231 nCPM
smooth muscle cells: 199 nCPM
decidual stromal cells: 164 nCPM
epididymal efferent duct absorptive cells: 155 nCPM
cytotrophoblasts: 151 nCPM
hofbauer cells: 145 nCPM

Immune cell

neutrophil: 3.4 nTPM
eosinophil: 2.3 nTPM
plasmacytoid DC: 1.6 nTPM
classical monocyte: 1.4 nTPM
intermediate monocyte: 1.1 nTPM
basophil: 0.9 nTPM

Brain region

hypothalamus: 31 nTPM
midbrain: 28 nTPM
pons: 27 nTPM
basal ganglia: 27 nTPM
medulla oblongata: 27 nTPM
thalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MSRB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DAOA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSRB2 as an antibody target. Whether an autoantibody or antibody against MSRB2 could matter depends on whether native MSRB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSRB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSRB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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