Seroatlas · Human Serome Atlas

MSRA

Mitochondrial peptide methionine sulfoxide reductase

Also known as: MSRA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJ68
Gene: MSRA
Ensembl: ENSG00000175806
Chromosome: 8
Canonical length: 235 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q9UJ68|MSRA
     1  MLSATRRACQ LLLLHSLFPV PRMGNSASNI VSPQEALPGR KEQTPVAAKH HVNGNRTVEP
    61  FPEGTQMAVF GMGCFWGAER KFWVLKGVYS TQVGFAGGYT SNPTYKEVCS EKTGHAEVVR
   121  VVYQPEHMSF EELLKVFWEN HDPTQGMRQG NDHGTQYRSA IYPTSAKQME AALSSKENYQ
   181  KVLSEHGFGP ITTDIREGQT FYYAEDYHQQ YLSKNPNGYC GLGGTGVSCP VGIKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSRA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

kidney: 86 nTPM
liver: 62 nTPM
cerebellum: 38 nTPM
heart muscle: 28 nTPM
cerebral cortex: 23 nTPM
hippocampal formation: 21 nTPM

Single-cell type

brain excitatory neurons: 929 nCPM
proximal tubule cells: 785 nCPM
bergmann glia: 499 nCPM
oligodendrocyte progenitor cells: 372 nCPM
brain inhibitory neurons: 365 nCPM
astrocytes: 321 nCPM

Immune cell

eosinophil: 5.7 nTPM
neutrophil: 2.2 nTPM
classical monocyte: 1.9 nTPM
myeloid DC: 1.3 nTPM
intermediate monocyte: 1.2 nTPM
non-classical monocyte: 1 nTPM

Brain region

cerebellum: 77 nTPM
cerebral cortex: 29 nTPM
hippocampal formation: 26 nTPM
white matter: 23 nTPM
basal ganglia: 22 nTPM
amygdala: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -2.63
DepMap mean gene effect: 0.22
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

L-methionine:thioredoxin-disulfide S-oxidoreductase activity
peptide-methionine (S)-S-oxide reductase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptide methionine sulphoxide reductase MsrA domain
Peptide methionine sulphoxide reductase MsrA superfamily
Methionine Sulfoxide Reductase A
Peptide methionine sulfoxide reductase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSRA as an antibody target. Whether an autoantibody or antibody against MSRA could matter depends on whether native MSRA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSRA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSRA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...