MSMP
Prostate-associated microseminoprotein
Also known as: MSMP_HUMAN, PC-3, PSMP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q1L6U9
- Gene
- MSMP
- Ensembl
- ENSG00000215183
- Chromosome
- 9
- Canonical length
- 139 aa
- Protein class
- Predicted secreted proteins
- Subcellular location
- Vesicles,Cytosol
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene encodes a member of the beta-microseminoprotein family. Members of this protein family contain ten conserved cysteine residues that form intra-molecular disulfide bonds. The encoded protein may play a role in prostate cancer tumorigenesis. [provided by RefSeq, Jan 2011]
Canonical amino-acid sequenceUniProt
139 residues, UniProt reviewed canonical sequence.
>Q1L6U9|MSMP
1 MALRMLWAGQ AKGILGGWGI ICLVMSLLLQ HPGVYSKCYF QAQAPCHYEG KYFTLGESWL
61 RKDCFHCTCL HPVGVGCCDT SQHPIDFPAG CEVRQEAGTC QFSLVQKSDP RLPCKGGGPD
121 PEWGSANTPV PGAPAPHSSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MSMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 3.1 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 3.1 nTPM
- pituitary gland: 1.3 nTPM
- placenta: 1.1 nTPM
- blood vessel: 0.7 nTPM
- skeletal muscle: 0.5 nTPM
- tongue: 0.4 nTPM
Single-cell type
- late spermatids: 326 nCPM
- early spermatids: 124 nCPM
- lymphatic endothelial cells: 28 nCPM
- cardiomyocytes: 11 nCPM
- hematopoietic stem cells: 4.4 nCPM
- platelets: 4.2 nCPM
Immune cell
- basophil: 0.7 nTPM
- MAIT T-cell: 0.3 nTPM
- NK-cell: 0.3 nTPM
- naive CD8 T-cell: 0.2 nTPM
- naive CD4 T-cell: 0.1 nTPM
- non-classical monocyte: 0.1 nTPM
Brain region
- medulla oblongata: 2.9 nTPM
- choroid plexus: 1.9 nTPM
- pons: 1.6 nTPM
- cerebral cortex: 1.3 nTPM
- amygdala: 0.8 nTPM
- spinal cord: 0.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.1
- gnomAD pLI
- 0.05
- gnomAD missense Z
- 0.06
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MSMP as an antibody target. Whether an autoantibody or antibody against MSMP could matter depends on whether native MSMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MSMP is annotated as secreted, so native MSMP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label MSMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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