Seroatlas · Human Serome Atlas

MSLNL

Mesothelin-like protein

Also known as: C16orf37, MPFL, MSLNL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KJ4
Gene: MSLNL
Ensembl: ENSG00000162006
Chromosome: 16
Canonical length: 702 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in cell-matrix adhesion. Predicted to be located in membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

702 residues, UniProt reviewed canonical sequence.

>Q96KJ4|MSLNL
     1  MAAAVTIPGP RIGALQSSGL TLLLSLAAHC SGPQAKVLSP GGLDASGANL WASANCSLLQ
    61  GFWCQPASQL PRDQLSALIQ RLALLQVPLQ AWQLSCLANL ASRCGLQDDF TLHPPNLLLF
   121  YNLSQVREAD CRAFIRRAAQ GDVELLSHLP DQRVALWRAA VACLVGAGLR LSASDQQLLG
   181  ALVCDMDASS IGAADPHMLE NLRRCPRLTA AQRIALNSLL AGGKTSLGPP GSWTLEGLQA
   241  LGPLATYISP HLWAQVQEAV GLGFFRSVVA SCQVGRLGQR EARCFVTSFL ESKTKPVSSR
   301  PRLSTGNITA ATLRDDLFLV HYDCAELESC LDGCILRTNL DTLLQHLLPT ECQHVVKAKL
   361  AQIYPQGLPE DQLRLITSLV YLYSRTEIGQ WSITSQDTVM ALLASDVALE NQTEAVLQKF
   421  LEHNGTVSGA LLLAIGGTRL CWMSPHQIQT IHPQELRLAG ALDLSSCPQS RKDVLYTKAH
   481  ETFGSSGTLA AYYRLMRPYL GGSPGGAQPP SPVPPGGAPV EELRHLAHAN ISMDIDTFTS
   541  LNPLELQSLD VGNVTALLGH NVGDLQKARS HPTVRAWLRS LNSSTLGQLG LDASPTSPTG
   601  PAHGTRGPPS TTHQVLHLVH TSGLPTNDAQ ASTSGSLWAP LGYLPLAMAL PCSLLCLLHW
   661  GTCILVSVDS VASGWLGSQG SGAGKTEVLD SAGRPLGLTG QL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSLNL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

epididymis: 0.6 nTPM
cerebral cortex: 0.5 nTPM
basal ganglia: 0.2 nTPM
stomach: 0.2 nTPM
fallopian tube: 0.1 nTPM
lung: 0.1 nTPM

Single-cell type

epicardial cells: 80 nCPM
retinal bipolar cells: 8.7 nCPM
endometrial luminal cells: 5.8 nCPM
endometrial glandular cells: 5.3 nCPM
conjunctival goblet cells: 4.9 nCPM
epididymal principal cells: 4.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.9 nTPM
basal ganglia: 0.6 nTPM
hippocampal formation: 0.3 nTPM
white matter: 0.3 nTPM
amygdala: 0.2 nTPM
cerebellum: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: -1.36

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell-matrix adhesion

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSLNL as an antibody target. Whether an autoantibody or antibody against MSLNL could matter depends on whether native MSLNL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSLNL is annotated at the cell surface, where native MSLNL is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MSLNL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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