Seroatlas · Human Serome Atlas

MSL3B

MSL complex subunit 3B

Also known as: MS3L2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C860
Gene: MSL3B
Canonical length: 356 aa

OverviewNCBI Gene

No narrative summary is available for MSL3B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>P0C860|MSL3B
     1  MEERTVTLEI PEVLKRQLED DCYYINRRKR LVQLPCHTNI ITILESYVKH FAISAAFSAN
    61  ERPRHHHAMP HASMNVPYIP AEKNIDLCKE MVDGLRITFD YTLPLVLLYP YEQAQYKKVT
   121  ASKVFLAIKE SATNTNRSQE KLSPSLRLLN PSRPQSTESQ STSGEPATPK RRKAEPQAVQ
   181  SLRRSSPHTA NCDRLSKSST SPQPKRWQQD MSTSVPKLFL HLEKKTPVHS RSSSPTLTPS
   241  QEGSPVFAGF EGRRTNEINE VLSWKLVPDN YPPGDQPPPP SYIYGAQHLL RLFVKLPEIL
   301  GKMSFTEKNL KALLKHFDLF VRFLAEYHDD FFPESAYVAA SEVHYSTRNP QAVNKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSL3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSL3B as an antibody target. Whether an autoantibody or antibody against MSL3B could matter depends on whether native MSL3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSL3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSL3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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