Seroatlas · Human Serome Atlas

MSGN1

Mesogenin-1

Also known as: MSGN1_HUMAN, pMesogenin1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NI15
Gene: MSGN1
Ensembl: ENSG00000151379
Chromosome: 2
Canonical length: 193 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Acrosome,Equatorial segment,Mid piece

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in mesoderm formation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within segment specification and somitogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>A6NI15|MSGN1
     1  MDNLRETFLS LEDGLGSSDS PGLLSSWDWK DRAGPFELNQ ASPSQSLSPA PSLESYSSSP
    61  CPAVAGLPCE HGGASSGGSE GCSVGGASGL VEVDYNMLAF QPTHLQGGGG PKAQKGTKVR
   121  MSVQRRRKAS EREKLRMRTL ADALHTLRNY LPPVYSQRGQ PLTKIQTLKY TIKYIGELTD
   181  LLNRGREPRA QSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSGN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 1.1 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 1.1 nTPM
esophagus: 0.2 nTPM
salivary gland: 0.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

sertoli cells: 1.1 nCPM
esophageal basal cells: 0.8 nCPM
choroid plexus epithelial cells: 0.6 nCPM
early spermatids: 0.5 nCPM
breast lactating cells: 0.4 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.3 nTPM
cerebral cortex: 0.3 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0.07
gnomAD missense Z: 0.6
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSGN1 as an antibody target. Whether an autoantibody or antibody against MSGN1 could matter depends on whether native MSGN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSGN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSGN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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