Seroatlas · Human Serome Atlas

MSANTD7

Myb/SANT-like DNA-binding domain-containing protein 7

Also known as: MSD7_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1W2PQ72
Gene
MSANTD7
Canonical length
361 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MSANTD7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>A0A1W2PQ72|MSANTD7
     1  MASANSSAGI RWSRQETRTL LSILGEAEYI QRLQTVHHNA DVYQAVSKRM QQEGFRRTER
    61  QCRSKFKVLK ALYLKAYVAH ATSMGEPPHC PFYDTLDQLL RNQIVTDPDN LMEDAAWAKH
   121  CDQNLVASDA PGEEGTGILK SKRTQAADHQ PILKTVKASD EDCQLRISDR IRETSDLEDS
   181  WDESSGAGCS QGTPSYSSSH SLFRGAVAPC QSSPMARLGV SGEPSPCTST NRSTPGVAST
   241  PQTPVSSSRA GFVSGGDRPL TSEPPPRWAR RRRRSVARTI AAELAENRRL ARELSKREEE
   301  KLDRLIAIGE EASAQQDTAN ELRRDAVIAV RRLATAVEEA TGAFQLGLEK LLQRLISNTK
   361  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSANTD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
9.3 nTPM

Expression across tissuesHPA

Tissue

  • retina: 9.3 nTPM
  • thymus: 9 nTPM
  • bone marrow: 8.4 nTPM
  • lymph node: 7.9 nTPM
  • placenta: 7.4 nTPM
  • skin: 7.2 nTPM

Single-cell type

  • megakaryocytes: 6.2 nCPM
  • melanocytes: 2.3 nCPM
  • conjunctival goblet cells: 1 nCPM
  • respiratory deuterosomal cells: 1 nCPM
  • salivary ionocytes: 0.7 nCPM
  • brain excitatory neurons: 0.5 nCPM

Immune cell

  • NK-cell: 3.5 nTPM
  • basophil: 2.9 nTPM
  • non-classical monocyte: 2.9 nTPM
  • naive CD8 T-cell: 2.5 nTPM
  • naive B-cell: 2.2 nTPM
  • plasmacytoid DC: 2.2 nTPM

Brain region

  • cerebellum: 19 nTPM
  • cerebral cortex: 14 nTPM
  • hippocampal formation: 13 nTPM
  • white matter: 13 nTPM
  • hypothalamus: 12 nTPM
  • basal ganglia: 11 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSANTD7 as an antibody target. Whether an autoantibody or antibody against MSANTD7 could matter depends on whether native MSANTD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSANTD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSANTD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MSANTD7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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