Seroatlas · Human Serome Atlas

MSANTD5

Uncharacterized protein MSANTD5

Also known as: MSD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A3B3IT52
Gene
MSANTD5
Ensembl
ENSG00000285891
Chromosome
5
Canonical length
213 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MSANTD5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>A0A3B3IT52|MSANTD5
     1  MEIVILPTET TINIQKMEQE NTAQGSEKPS VQSVKPWSDQ EIRSFLQEWE FLEREVYRVK
    61  KKYHIVSKAI AQRLKQRGIN KSWKECLQML ISLQDLYFTI QEANQRPRCQ PLPCPYGEAL
   121  HRILGYRWKI SVFSGPPCAD VVNLAPPEHP PQAYGVPIVF QEPMWAPTPV IYVENPQVPG
   181  WEPWNMNGHV PYMYPALPPA APGPLTQWAI STD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSANTD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
2.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 2.4 nTPM
  • amygdala: 0.1 nTPM
  • epididymis: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • retina: 0.1 nTPM

Single-cell type

  • late spermatids: 2.2 nCPM
  • late primary spermatocytes: 0.5 nCPM
  • early spermatids: 0.3 nCPM
  • brain excitatory neurons: 0.1 nCPM
  • brain inhibitory neurons: 0.1 nCPM
  • early primary spermatocytes: 0.1 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 2.3 nTPM
  • cerebral cortex: 2.1 nTPM
  • thalamus: 1.8 nTPM
  • hypothalamus: 1.7 nTPM
  • medulla oblongata: 1.6 nTPM
  • white matter: 1.6 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSANTD5 as an antibody target. Whether an autoantibody or antibody against MSANTD5 could matter depends on whether native MSANTD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSANTD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSANTD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MSANTD5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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