Seroatlas · Human Serome Atlas

MSANTD3

Myb/SANT-like DNA-binding domain-containing protein 3

Also known as: C9orf30, MGC17337, MSD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96H12
Gene: MSANTD3
Ensembl: ENSG00000066697
Chromosome: 9
Canonical length: 275 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

No narrative summary is available for MSANTD3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q96H12|MSANTD3
     1  MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ ALAHEYNSQP
    61  SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL LSTHVLGKEK IASMLPEQLY
   121  FLQSPPEEEP EYHPDASAQE SFAVSNRELC DDEKEFIHFP VCEGTSQPEP SCSAVRITAN
   181  KNYRSKTSQE GALKKMHEEE HHQQMSILQL QLIQMNEVHV AKIQQIEREC EMAEEEHRIK
   241  MEVLNKKKMY WERKLQTFTK EWPVSSFNRP FPNSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSANTD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

tongue: 26 nTPM
skeletal muscle: 20 nTPM
heart muscle: 16 nTPM
urinary bladder: 15 nTPM
midbrain: 15 nTPM
spinal cord: 14 nTPM

Single-cell type

brain excitatory neurons: 37 nCPM
other brain neurons: 35 nCPM
platelets: 35 nCPM
oligodendrocyte progenitor cells: 32 nCPM
brain inhibitory neurons: 32 nCPM
oligodendrocytes: 32 nCPM

Immune cell

basophil: 8 nTPM
MAIT T-cell: 3.8 nTPM
NK-cell: 3.7 nTPM
memory CD8 T-cell: 3.2 nTPM
naive B-cell: 2.8 nTPM
naive CD4 T-cell: 2.8 nTPM

Brain region

cerebral cortex: 41 nTPM
white matter: 38 nTPM
cerebellum: 33 nTPM
midbrain: 33 nTPM
hypothalamus: 30 nTPM
pons: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.02
gnomAD missense Z: 1.35
DepMap mean gene effect: -0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSANTD3 as an antibody target. Whether an autoantibody or antibody against MSANTD3 could matter depends on whether native MSANTD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSANTD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSANTD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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