Seroatlas · Human Serome Atlas

MSANTD2

Myb/SANT-like DNA-binding domain-containing protein 2

Also known as: C11orf61, FLJ23342, MSD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P1R3
Gene: MSANTD2
Ensembl: ENSG00000120458
Chromosome: 11
Canonical length: 559 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

No narrative summary is available for MSANTD2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>Q6P1R3|MSANTD2
     1  MAAPCGSELP ANSPLKIPKM EVLSPASPGG LSDGNPSLSD PSTPRGASPL GPGSAAGSGA
    61  AASGGLGLGL GGRSAASSSV SFSPGGGGGG AAAAAAAACR GMSWTPAETN ALIAVWGNER
   121  LVEARYQQLE GAGTVFGSKA PGPAMYERVS RALAELGYER TPSQCRERIK TLRRCYSRVK
   181  EHGVGKRKSS YTFEQLEQVF GQGGWDAQPC QPVLINSSGL YQELESDGST MEDYSQEDWG
   241  NHSQDLHGYP TDQELDEIPV TKRTLKIKQE SSEEAQKRDI MQNIVQILES VQLKWELFQS
   301  WTDFSRLHLS NKLAIFGIGY NTRWKEDIRY HYAEISSQVP LGKRLREYFN SEKPEGRIIM
   361  TRVQKMNWKN VYYKFLEITI SEARCLELHM EIDWIPIAHS KPTGGNVVQY LLPGGIPKSP
   421  GLYAIGYEEC IERPLSPHME QSSLDPGKEG RVDLETLSAQ ASLQVEIEPT RIIYCYLGIA
   481  EVRTLQQCLF LHFQANTKTF SKDWVGINGF LSQNCIVDPG VSPKSIYIKF VEVERDFLSA
   541  GSLVECLEKA IGYPLKFNN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSANTD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 22 nTPM
kidney: 14 nTPM
pituitary gland: 13 nTPM
cervix: 12 nTPM
pancreas: 12 nTPM
ovary: 11 nTPM

Single-cell type

loop of henle epithelial cells: 83 nCPM
lactotrophs: 82 nCPM
choroid plexus epithelial cells: 76 nCPM
somatotrophs: 70 nCPM
distal convoluted tubule cells: 70 nCPM
microglia: 65 nCPM

Immune cell

T-reg: 1.1 nTPM
memory CD8 T-cell: 0.9 nTPM
naive B-cell: 0.8 nTPM
eosinophil: 0.6 nTPM
gdT-cell: 0.6 nTPM
memory CD4 T-cell: 0.5 nTPM

Brain region

white matter: 15 nTPM
basal ganglia: 11 nTPM
pons: 11 nTPM
midbrain: 11 nTPM
choroid plexus: 11 nTPM
hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.9
gnomAD missense Z: 2.3
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Myb/SANT-like DNA-binding domain 4
Myb/SANT-like DNA-binding domain
Myb/SANT-like DNA-binding domain-containing protein 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSANTD2 as an antibody target. Whether an autoantibody or antibody against MSANTD2 could matter depends on whether native MSANTD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSANTD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSANTD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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