Seroatlas · Human Serome Atlas

MSANTD1

Myb/SANT-like DNA-binding domain-containing protein 1

Also known as: C4orf44, LOC345222, MSD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZTZ1
Gene: MSANTD1
Ensembl: ENSG00000188981
Chromosome: 4
Canonical length: 278 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q6ZTZ1|MSANTD1
     1  MVRGAGPGPS LSALSHPTGA SGMAAAEGPG YLVSPQAEKH RRARNWTDAE MRGLMLVWEE
    61  FFDELKQTKR NAKVYEKMAS KLFEMTGERR LGEEIKIKIT NMTFQYRKLK CMTDSESAPP
   121  DWPYYLAIDG ILAKVPESCD GKLPDSQPPG PSTSQTEASL SPPAKSTPLY FPYNQCSYEG
   181  RFEDDRSDSS SSLLSLKFRS EERPVKKRKV QSCHLQKKQL RLLEAMVEEQ RRLSRAVEET
   241  CREVRRVLDQ QHILQVQSLQ LQERMMSLLE RIITKSSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSANTD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 5.7 nTPM
hypothalamus: 4.6 nTPM
testis: 3.9 nTPM
cerebral cortex: 3.3 nTPM
amygdala: 2.8 nTPM
hippocampal formation: 2.6 nTPM

Single-cell type

early spermatids: 47 nCPM
late spermatids: 46 nCPM
late primary spermatocytes: 14 nCPM
pancreatic islet cells: 13 nCPM
myonuclei: 13 nCPM
sertoli cells: 11 nCPM

Immune cell

naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 13 nTPM
basal ganglia: 9.9 nTPM
hippocampal formation: 8.6 nTPM
cerebral cortex: 8.5 nTPM
amygdala: 8.3 nTPM
midbrain: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.8
gnomAD missense Z: 0.75
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of DNA-templated transcription

Cellular components

nuclear body

Protein domainsUniProt · Pfam · InterPro

Myb/SANT-like DNA-binding domain 4
Myb/SANT-like DNA-binding domain
Myb/SANT-like DNA-binding domain-containing protein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSANTD1 as an antibody target. Whether an autoantibody or antibody against MSANTD1 could matter depends on whether native MSANTD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSANTD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSANTD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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