MS4A6E
Membrane-spanning 4-domains subfamily A member 6E
Also known as: M4A6E_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96DS6
- Gene
- MS4A6E
- Ensembl
- ENSG00000166926
- Chromosome
- 11
- Canonical length
- 147 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
147 residues, UniProt reviewed canonical sequence.
>Q96DS6|MS4A6E
1 MTSQPISNET IIMLPSNVIN FSQAEKPEPT NQGQDSLKKR LQAKVKVIGV HSSLAGSILS
61 ALSALVGFIL LSVNPAALNP ASLQCKLDEK DIPTRLLLSY DYHSPYTMDC HRAKASLAGT
121 LSLMLVSTVL EFCLAVLTAV LQWKQTVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MS4A6E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- testis: 19 nTPM
- appendix: 0.6 nTPM
- spleen: 0.3 nTPM
- adipose tissue: 0.2 nTPM
- liver: 0.1 nTPM
- lung: 0.1 nTPM
Single-cell type
- early spermatids: 1,754 nCPM
- late primary spermatocytes: 450 nCPM
- late spermatids: 196 nCPM
- kupffer cells: 26 nCPM
- macrophages: 18 nCPM
- monocytes: 13 nCPM
Immune cell
- intermediate monocyte: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- pons: 0.8 nTPM
- cerebral cortex: 0.2 nTPM
- medulla oblongata: 0.2 nTPM
- thalamus: 0.2 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.31
- gnomAD pLI
- 0.03
- gnomAD missense Z
- -0.5
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MS4A6E as an antibody target. Whether an autoantibody or antibody against MS4A6E could matter depends on whether native MS4A6E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MS4A6E is annotated at the cell surface, where native MS4A6E is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MS4A6E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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