Seroatlas · Human Serome Atlas

MS4A4E

Putative membrane-spanning 4-domains subfamily A member 4E

Also known as: M4A4E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PG1
Gene
MS4A4E
Ensembl
ENSG00000214787
Chromosome
11
Canonical length
132 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Most MS4A genes, including MS4A4E, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q96PG1|MS4A4E
     1  MTTMQGMEQT TPGAGPDVPQ LGNIDVIHSY LCKGLQEKFF KRKPKVLGVV RILIALMSLS
    61  MGIIMMCVAF SSYEEHPIFV YVAYTIWGSV MYPYQLQQEL EQQKVWNYLK NLSWRIMGSY
   121  LCFGERSELK PL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A4E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
8.9 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 8.9 nTPM
  • bone marrow: 6.3 nTPM
  • liver: 5.4 nTPM
  • adipose tissue: 5.3 nTPM
  • skeletal muscle: 5.2 nTPM
  • retina: 4.8 nTPM

Single-cell type

  • monocyte progenitors: 330 nCPM
  • cdc: 277 nCPM
  • macrophages: 253 nCPM
  • kupffer cells: 248 nCPM
  • mast cells: 191 nCPM
  • monocytes: 99 nCPM

Immune cell

  • basophil: 18 nTPM
  • neutrophil: 3.2 nTPM
  • myeloid DC: 2.2 nTPM
  • classical monocyte: 1.5 nTPM
  • intermediate monocyte: 1.5 nTPM
  • plasmacytoid DC: 1.5 nTPM

Brain region

  • cerebellum: 34 nTPM
  • cerebral cortex: 30 nTPM
  • hippocampal formation: 28 nTPM
  • white matter: 28 nTPM
  • amygdala: 27 nTPM
  • basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.89
gnomAD pLI
0
gnomAD missense Z
0.21

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A4E as an antibody target. Whether an autoantibody or antibody against MS4A4E could matter depends on whether native MS4A4E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A4E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MS4A4E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MS4A4E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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