Seroatlas · Human Serome Atlas

MRTO4

mRNA turnover protein 4 homolog

Also known as: C1orf33, dJ657E11.4, MRT4, MRT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKD2
Gene
MRTO4
Ensembl
ENSG00000053372
Chromosome
1
Canonical length
239 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Nucleoli

OverviewNCBI Gene

This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q9UKD2|MRTO4
     1  MPKSKRDKKV SLTKTAKKGL ELKQNLIEEL RKCVDTYKYL FIFSVANMRN SKLKDIRNAW
    61  KHSRMFFGKN KVMMVALGRS PSDEYKDNLH QVSKRLRGEV GLLFTNRTKE EVNEWFTKYT
   121  EMDYARAGNK AAFTVSLDPG PLEQFPHSME PQLRQLGLPT ALKRGVVTLL SDYEVCKEGD
   181  VLTPEQARVL KLFGYEMAEF KVTIKYMWDS QSGRFQQMGD DLPESASEST EESDSEDDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRTO4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 26 nTPM
  • pancreas: 25 nTPM
  • cerebral cortex: 25 nTPM
  • skeletal muscle: 24 nTPM
  • amygdala: 23 nTPM
  • hippocampal formation: 22 nTPM

Single-cell type

  • esophageal basal cells: 128 nCPM
  • erythrocyte progenitors: 90 nCPM
  • migrating cytotrophoblasts: 89 nCPM
  • late primary spermatocytes: 82 nCPM
  • differentiating spermatogonia: 76 nCPM
  • extravillous trophoblasts: 72 nCPM

Immune cell

  • memory B-cell: 23 nTPM
  • MAIT T-cell: 23 nTPM
  • naive B-cell: 20 nTPM
  • plasmacytoid DC: 20 nTPM
  • naive CD4 T-cell: 19 nTPM
  • myeloid DC: 18 nTPM

Brain region

  • cerebral cortex: 21 nTPM
  • hippocampal formation: 21 nTPM
  • basal ganglia: 20 nTPM
  • thalamus: 19 nTPM
  • amygdala: 19 nTPM
  • midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
0.99
gnomAD missense Z
-0.04
DepMap mean gene effect
-0.9
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRTO4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • MINAS-60

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRTO4 as an antibody target. Whether an autoantibody or antibody against MRTO4 could matter depends on whether native MRTO4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRTO4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRTO4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRTO4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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